Abstract
In this paper, we report the synthesis, characterization and investigation of the optical properties of a new fluorescent probe, 4ʹ-nitroolefinylflavone (4ʹ-NOF) 1, based on a flavone skeleton and bearing a nitroolefin moiety. Upon the addition of cysteine, a remarkable fluorescence enhancement (200 fold) was observed for probe 1 accompanied with a slight blue shift from 457 nm to 459 nm. The prepared probe displays high selectivity and sensitivity towards cysteine over other amino acids. The Michael addition of cysteine to probe 1 was confirmed by 1H-NMR spectroscopy. The detection limit of probe 1 towards cysteine was found to be 1.63 μΜ, a lower concentration than the normal human cysteine level, 30-200 μΜ.
Keywords
Subject
Publication details
- DOI
- 10.24200/squjs.vol23iss2pp85-94
- Journal
- Sultan Qaboos University Journal for Science, 23(2), 85
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY 4.0
Cite this article
APA 7
N., A. B. S., M., A. H. N., Eldin, O. S. F., & Beena, V. (2018). Synthesis of a Flavone Based Fluorescent Probe Bearing a Nitroolefin Moiety for Selective Detection of Cysteine. Sultan Qaboos University Journal for Science, 23(2), 85. https://doi.org/10.24200/squjs.vol23iss2pp85-94
MLA 9
N., Al-Busafi Saleh, et al. "Synthesis of a Flavone Based Fluorescent Probe Bearing a Nitroolefin Moiety for Selective Detection of Cysteine." Sultan Qaboos University Journal for Science, vol. 23, no. 2, 2018, pp. 85. https://doi.org/10.24200/squjs.vol23iss2pp85-94.
Chicago (author–date)
N., Al-Busafi Saleh, Al-Hamami Nadia M., O. Suliman Fakhr Eldin, and Varghese Beena. 2018. "Synthesis of a Flavone Based Fluorescent Probe Bearing a Nitroolefin Moiety for Selective Detection of Cysteine." Sultan Qaboos University Journal for Science 23 (2): 85. https://doi.org/10.24200/squjs.vol23iss2pp85-94.
Harvard
N., A. B. S., M., A. H. N., Eldin, O. S. F. and Beena, V. (2018) 'Synthesis of a Flavone Based Fluorescent Probe Bearing a Nitroolefin Moiety for Selective Detection of Cysteine', Sultan Qaboos University Journal for Science, 23(2), pp. 85. doi:10.24200/squjs.vol23iss2pp85-94.
Vancouver
N. ABS, M. AHN, Eldin OSF, Beena V. Synthesis of a Flavone Based Fluorescent Probe Bearing a Nitroolefin Moiety for Selective Detection of Cysteine. Sultan Qaboos University Journal for Science. 2018;23(2):85. doi:10.24200/squjs.vol23iss2pp85-94
IEEE
A. B. S. N., A. H. N. M., O. S. F. Eldin, and V. Beena, "Synthesis of a Flavone Based Fluorescent Probe Bearing a Nitroolefin Moiety for Selective Detection of Cysteine," Sultan Qaboos University Journal for Science, vol. 23, no. 2, pp. 85, 2018, doi: 10.24200/squjs.vol23iss2pp85-94.