Abstract
Statins are potent medications which reduce low-density lipoprotein cholesterol (LDL-C) levels. Their efficacy in cardiovascular risk reduction is well established and indications for their use are expanding. While statins are generally well tolerated and safe, adverse events are relatively common, particularly statinassociated muscle adverse events (SaMAEs), which are the most frequently encountered type of adverse event. Recent guidelines and guideline updates on SaMAEs and statin intolerance have included revised definitions of SaMAEs, incorporating new evidence on their pathogenesis and management. As SaMAEs emerge as a therapeutic challenge, it is important for physicians to be aware of updates on management strategies to ensure better patient outcomes. The majority of patients who are considered statin-intolerant can nevertheless tolerate some forms of statin therapy and successfully achieve optimal LDL-C levels. This review article discusses the recent classification of SaMAEs with emphasis on pathogenesis and management strategies.
Publication details
- DOI
- 10.18295/squmj.2016.16.04.002
- Journal
- Sultan Qaboos University Medical Journal, 16(4), 406-415
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY-ND 4.0
Cite this article
APA 7
Al-Mohaissen, M. A., Ignaszewski, M. J., Ignaszewski, J., & P., A. (2025). Statin-Associated Muscle Adverse Events: Update for clinicians. Sultan Qaboos University Medical Journal, 16(4), 406-415. https://doi.org/10.18295/squmj.2016.16.04.002
MLA 9
Al-Mohaissen, Maha A., et al. "Statin-Associated Muscle Adverse Events: Update for clinicians." Sultan Qaboos University Medical Journal, vol. 16, no. 4, 2025, pp. 406-415. https://doi.org/10.18295/squmj.2016.16.04.002.
Chicago (author–date)
Al-Mohaissen, Maha A., Martha J. Ignaszewski, Jiri Ignaszewski, and Andrew P. 2025. "Statin-Associated Muscle Adverse Events: Update for clinicians." Sultan Qaboos University Medical Journal 16 (4): 406-415. https://doi.org/10.18295/squmj.2016.16.04.002.
Harvard
Al-Mohaissen, M. A., Ignaszewski, M. J., Ignaszewski, J. and P., A. (2025) 'Statin-Associated Muscle Adverse Events: Update for clinicians', Sultan Qaboos University Medical Journal, 16(4), pp. 406-415. doi:10.18295/squmj.2016.16.04.002.
Vancouver
Al-Mohaissen MA, Ignaszewski MJ, Ignaszewski J, P. A. Statin-Associated Muscle Adverse Events: Update for clinicians. Sultan Qaboos University Medical Journal. 2025;16(4):406-415. doi:10.18295/squmj.2016.16.04.002
IEEE
M. A. Al-Mohaissen, M. J. Ignaszewski, J. Ignaszewski, and A. P., "Statin-Associated Muscle Adverse Events: Update for clinicians," Sultan Qaboos University Medical Journal, vol. 16, no. 4, pp. 406-415, 2025, doi: 10.18295/squmj.2016.16.04.002.