Abstract
First discovered by Friedenstein in 1976, mesenchymal stem cells (MSCs) are adult stem cells found throughout the body that share a fixed set of characteristics. Discovered initially in the bone marrow, this cell source is considered the gold standard for clinical research, although various other sources—including adipose tissue, dental pulp, mobilised peripheral blood and birth-derived tissues—have since been identified. Although similar, MSCs derived from different sources possess distinct characteristics, advantages and disadvantages, including their differentiation potential and proliferation capacity, which influence their applicability. Hence, they may be used for specific clinical applications in the fields of regenerative medicine and tissue engineering. This review article summarises current knowledge regarding the various sources, characteristics and therapeutic applications of MSCs.
Publication details
- DOI
- 10.18295/squmj.2018.18.03.002
- Journal
- Sultan Qaboos University Medical Journal, 18(3), e264-277
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY-ND 4.0
Cite this article
APA 7
Berebichez-Fridman, R., & Montero-Olvera, P. R. (2025). Sources and Clinical Applications of Mesenchymal Stem Cells: State-of-the-art review. Sultan Qaboos University Medical Journal, 18(3), e264-277. https://doi.org/10.18295/squmj.2018.18.03.002
MLA 9
Berebichez-Fridman, Roberto, and Pablo R. Montero-Olvera. "Sources and Clinical Applications of Mesenchymal Stem Cells: State-of-the-art review." Sultan Qaboos University Medical Journal, vol. 18, no. 3, 2025, pp. e264-277. https://doi.org/10.18295/squmj.2018.18.03.002.
Chicago (author–date)
Berebichez-Fridman, Roberto, and Pablo R. Montero-Olvera. 2025. "Sources and Clinical Applications of Mesenchymal Stem Cells: State-of-the-art review." Sultan Qaboos University Medical Journal 18 (3): e264-277. https://doi.org/10.18295/squmj.2018.18.03.002.
Harvard
Berebichez-Fridman, R. and Montero-Olvera, P. R. (2025) 'Sources and Clinical Applications of Mesenchymal Stem Cells: State-of-the-art review', Sultan Qaboos University Medical Journal, 18(3), pp. e264-277. doi:10.18295/squmj.2018.18.03.002.
Vancouver
Berebichez-Fridman R, Montero-Olvera PR. Sources and Clinical Applications of Mesenchymal Stem Cells: State-of-the-art review. Sultan Qaboos University Medical Journal. 2025;18(3):e264-277. doi:10.18295/squmj.2018.18.03.002
IEEE
R. Berebichez-Fridman, and P. R. Montero-Olvera, "Sources and Clinical Applications of Mesenchymal Stem Cells: State-of-the-art review," Sultan Qaboos University Medical Journal, vol. 18, no. 3, pp. e264-277, 2025, doi: 10.18295/squmj.2018.18.03.002.