Abstract
Sodium-glucose cotransporter type 2 inhibitors (SGLT2i) are oral hypoglycemic agents that have insulin-independent glucose-lowering effects mediated by increasing the renal excretion of glucose by inhibiting the SGLT2-mediated renal glucose reabsorption. An increasingly recognized complication induced by SGLT2i is euglycemic diabetic ketoacidosis (eDKA). Here, we describe the case of a 26-year-old male patient with type 2 diabetes mellitus and morbid obesity. Prior to presentation he was on multiple oral hypoglycemic agents including SGLT2i. He developed life-threatening severe prolonged eDKA associated with SGLT2i (Canagliflozin), precipitated by adenovirus infection. The acidosis was not responding to standard DKA therapy and renal replacement therapy but was managed effectively with insulin titration based on capillary ketone measurements. After reviewing the literature on severe prolonged eDKA induced by SGLT2 and treatment modalities used, we present previously reported cases similar to ours.
Keywords
Publication details
- DOI
- 10.5001/omj.2022.17
- Journal
- Oman Medical Journal
- Publisher
- Oman Medical Specialty Board
- Open access
- Gold open access
Cite this article
APA 7
Almazrouei, R., Alkindi, F., Alshamsi, A., Dawoud, T., Chaaban, A., & Rahman, M. U. (2022). Severe Prolonged SGLT2i-induced Euglycemic Diabetic Ketoacidosis Refractory to Standard Therapy and Dialysis: Case Report and Literature Review. Oman Medical Journal. https://doi.org/10.5001/omj.2022.17
MLA 9
Almazrouei, Raya, et al. "Severe Prolonged SGLT2i-induced Euglycemic Diabetic Ketoacidosis Refractory to Standard Therapy and Dialysis: Case Report and Literature Review." Oman Medical Journal, 2022. https://doi.org/10.5001/omj.2022.17.
Chicago (author–date)
Almazrouei, Raya, Fatima Alkindi, Aisha Alshamsi, Tasnim Dawoud, Ahmad Chaaban, and Masood Ur Rahman. 2022. "Severe Prolonged SGLT2i-induced Euglycemic Diabetic Ketoacidosis Refractory to Standard Therapy and Dialysis: Case Report and Literature Review." Oman Medical Journal. https://doi.org/10.5001/omj.2022.17.
Harvard
Almazrouei, R., Alkindi, F., Alshamsi, A., Dawoud, T., Chaaban, A. and Rahman, M. U. (2022) 'Severe Prolonged SGLT2i-induced Euglycemic Diabetic Ketoacidosis Refractory to Standard Therapy and Dialysis: Case Report and Literature Review', Oman Medical Journal. doi:10.5001/omj.2022.17.
Vancouver
Almazrouei R, Alkindi F, Alshamsi A, Dawoud T, Chaaban A, Rahman MU. Severe Prolonged SGLT2i-induced Euglycemic Diabetic Ketoacidosis Refractory to Standard Therapy and Dialysis: Case Report and Literature Review. Oman Medical Journal. 2022. doi:10.5001/omj.2022.17
IEEE
R. Almazrouei, F. Alkindi, A. Alshamsi, T. Dawoud, A. Chaaban, and M. U. Rahman, "Severe Prolonged SGLT2i-induced Euglycemic Diabetic Ketoacidosis Refractory to Standard Therapy and Dialysis: Case Report and Literature Review," Oman Medical Journal, 2022, doi: 10.5001/omj.2022.17.