Abstract
Objectives: To investigate the incidence and associated risk factors of adverse events following COVID-19 vaccination in patients with inflammatory and non-inflammatory rheumatic and musculoskeletal diseases (I-RMD and NI-RMD, respectively). Methods: The Egyptian College of Rheumatology COVID-19 Study Group investigated physician-reported data (ECR-VaXurvey3) of RMD patients vaccinated against COVID-19 from December 2021 to June 2022, including their demographics, vaccination type, RMD diagnosis, treatments, post-vaccine flares, and other adverse events. The control group consisted of healthy, vaccinated individuals. Results: The ECR-VaXurvey3 included 890 vaccinated RMD patients, predominantly women (73.3%) with a mean age of 44.4 ± 12.1 years, and 172 controls. The RMD group comprised 816 (91.7%) with I-RMD and 74 (8.3%) with NI-RMD. The frequency of adverse events was comparable between the RMD and control groups. In RMD patients, injection site pain (59.9%) was the most reported adverse event. Post-vaccination COVID-19 infections and disease flares were reported in 2.9% and 12.1% of I-RMD patients and in 8.1% and 9.5% of NI-RMD patients (p = 0.018 and p = 0.497, respectively). The severity of prior COVID-19 infection (odds ratio (OR) = 2.4, 95% CI: 1.0–5.8; p = 0.040) and azathioprine use (OR = 2.6, 95% CI: 1.1–5.9; p = 0.024) were associated with higher post-vaccine adverse events, while biologic use was associated with fewer adverse events (OR = 0.5, 95% CI: 0.3–0.8; p = 0.010). Conclusions: Adverse events following COVID-19 vaccinations in patients with RMD are comparable to controls.
Keywords
Publication details
- DOI
- 10.5001/omj.2024.107
- Journal
- Oman Medical Journal
- Publisher
- Oman Medical Specialty Board
- Open access
- Gold open access
Cite this article
APA 7
Hammam, N., Mosad, D., Ibrahim, A. M., Abdel-Fattah, Y. H., Aly, H. M., El-Saadany, H. M., Nassr, M., Moshrif, A., Fathi, H. M., Nasef, S. I., Ismail, F., El Shereef, R. R., Hammam, O., Abd-Elazeem, M. I., Abdelaleem, E. A., Elsayed, A. M., Tharwat, S., & Gheita, T. A. (2024). Safety of COVID-19 Vaccination in Patients with Rheumatic and Musculoskeletal Diseases: A Cross-sectional Study in Egypt. Oman Medical Journal. https://doi.org/10.5001/omj.2024.107
MLA 9
Hammam, Nevin, et al. "Safety of COVID-19 Vaccination in Patients with Rheumatic and Musculoskeletal Diseases: A Cross-sectional Study in Egypt." Oman Medical Journal, 2024. https://doi.org/10.5001/omj.2024.107.
Chicago (author–date)
Hammam, Nevin, Doaa Mosad, Amira M. Ibrahim, Yousra H. Abdel-Fattah, Hany M. Aly, Hanan M. El-Saadany, Maha Nassr, Abdelhafeez Moshrif, Hanan M. Fathi, Samah I. Nasef, Faten Ismail, Rawhya R. El Shereef, Osman Hammam, Mervat I. Abd-Elazeem, Enas A. Abdelaleem, Abdelrahman Mohamed Elsayed, Samar Tharwat, and Tamer A. Gheita. 2024. "Safety of COVID-19 Vaccination in Patients with Rheumatic and Musculoskeletal Diseases: A Cross-sectional Study in Egypt." Oman Medical Journal. https://doi.org/10.5001/omj.2024.107.
Harvard
Hammam, N., Mosad, D., Ibrahim, A. M., Abdel-Fattah, Y. H., Aly, H. M., El-Saadany, H. M., Nassr, M., Moshrif, A., Fathi, H. M., Nasef, S. I., Ismail, F., El Shereef, R. R., Hammam, O., Abd-Elazeem, M. I., Abdelaleem, E. A., Elsayed, A. M., Tharwat, S. and Gheita, T. A. (2024) 'Safety of COVID-19 Vaccination in Patients with Rheumatic and Musculoskeletal Diseases: A Cross-sectional Study in Egypt', Oman Medical Journal. doi:10.5001/omj.2024.107.
Vancouver
Hammam N, Mosad D, Ibrahim AM, Abdel-Fattah YH, Aly HM, El-Saadany HM, et al. Safety of COVID-19 Vaccination in Patients with Rheumatic and Musculoskeletal Diseases: A Cross-sectional Study in Egypt. Oman Medical Journal. 2024. doi:10.5001/omj.2024.107
IEEE
N. Hammam, D. Mosad, A. M. Ibrahim, Y. H. Abdel-Fattah, H. M. Aly, H. M. El-Saadany, M. Nassr, A. Moshrif, H. M. Fathi, S. I. Nasef, F. Ismail, R. R. El Shereef, O. Hammam, M. I. Abd-Elazeem, E. A. Abdelaleem, A. M. Elsayed, S. Tharwat, and T. A. Gheita, "Safety of COVID-19 Vaccination in Patients with Rheumatic and Musculoskeletal Diseases: A Cross-sectional Study in Egypt," Oman Medical Journal, 2024, doi: 10.5001/omj.2024.107.