Abstract
Lung carcinoma is the leading cause of cancer-related deaths and is the primary source for choroidal metastasis in over 20% cases. Non-small-cell lung cancer (NSCLC) accounts for 85% of all lung cancer cases. Patients with metastatic NSCLC have a median survival of one year. Successful treatment of systemic metastasis from NSCLC using erlotinib has been documented. The effect of oral erlotinib on choroidal metastasis has been rarely reported. We document a case and study the effect of oral erlotinib on choroidal metastasis from NSCLC. A 48-year-old Caucasian female presented with biopsy-proven primary NSCLC with systemic metastasis and solitary choroidal metastasis of 4.8 mm thickness in the right eye. The patient was treated with 100 mg daily dose of oral erlotinib. Two weeks after starting erlotinib therapy, the patient showed complete regression of choroidal metastasis to a flat scar with resolution of subretinal fluid and improvement of visual acuity from 20/100 to 20/25. There was no evidence of recurrence at five-month follow-up. Erlotinib is an alternative therapy for choroidal metastasis from NSCLC.
Keywords
Publication details
- DOI
- 10.4103/0974-620x.137159
- Journal
- Oman Journal of Ophthalmology, 7(2), 75-77
- Publisher
- Medknow Publications
- Open access
- Gold open access
Cite this article
APA 7
Ye, X., Kaliki, S., & Shields, C. L. (2014). Rapid regression of choroidal metastasis from lung cancer using erlotinib (Tarceva). Oman Journal of Ophthalmology, 7(2), 75-77. https://doi.org/10.4103/0974-620x.137159
MLA 9
Ye, Xuemei, et al. "Rapid regression of choroidal metastasis from lung cancer using erlotinib (Tarceva)." Oman Journal of Ophthalmology, vol. 7, no. 2, 2014, pp. 75-77. https://doi.org/10.4103/0974-620x.137159.
Chicago (author–date)
Ye, Xuemei, Swathi Kaliki, and Carol L Shields. 2014. "Rapid regression of choroidal metastasis from lung cancer using erlotinib (Tarceva)." Oman Journal of Ophthalmology 7 (2): 75-77. https://doi.org/10.4103/0974-620x.137159.
Harvard
Ye, X., Kaliki, S. and Shields, C. L. (2014) 'Rapid regression of choroidal metastasis from lung cancer using erlotinib (Tarceva)', Oman Journal of Ophthalmology, 7(2), pp. 75-77. doi:10.4103/0974-620x.137159.
Vancouver
Ye X, Kaliki S, Shields CL. Rapid regression of choroidal metastasis from lung cancer using erlotinib (Tarceva). Oman Journal of Ophthalmology. 2014;7(2):75-77. doi:10.4103/0974-620x.137159
IEEE
X. Ye, S. Kaliki, and C. L. Shields, "Rapid regression of choroidal metastasis from lung cancer using erlotinib (Tarceva)," Oman Journal of Ophthalmology, vol. 7, no. 2, pp. 75-77, 2014, doi: 10.4103/0974-620x.137159.