Abstract
Quinazolinone and quinazoline have been shown different pharmacological activities, namely anticancer, anti-inflammatory, anti-hyperlipidemia, analgesic, antihypertensive, and antibacterial. On the other hand, molecular hybridization is a structural modification technique in the design of new ligands which consist of two or more pharmacologically active molecules in one structure. Therefore, due to the importance of the biological activities of quinazolinones for the development of new therapeutic agents, this review emphasizes current findings on various quinazolinone-based hybrids in medicinal chemistry. Moreover, it highlights the biological activities and structure-activity relationship of these hybrids.
Keywords
Subject
Publication details
- DOI
- 10.4103/jrms.jrms_1025_21
- Journal
- Journal of Research in Medical Sciences, 27(1), 68
- Publisher
- Wolters Kluwer Medknow Publications
- Open access
- Gold open access
- License
- CC BY-NC-SA 4.0
Cite this article
APA 7
Rezaeinasab, R., Jafari, E., & Khodarahmi, G. (2022). Quinazolinone-based hybrids with diverse biological activities. Journal of Research in Medical Sciences, 27(1), 68. https://doi.org/10.4103/jrms.jrms_1025_21
MLA 9
Rezaeinasab, Rezvan, et al. "Quinazolinone-based hybrids with diverse biological activities." Journal of Research in Medical Sciences, vol. 27, no. 1, 2022, pp. 68. https://doi.org/10.4103/jrms.jrms_1025_21.
Chicago (author–date)
Rezaeinasab, Rezvan, Elham Jafari, and Ghadamali Khodarahmi. 2022. "Quinazolinone-based hybrids with diverse biological activities." Journal of Research in Medical Sciences 27 (1): 68. https://doi.org/10.4103/jrms.jrms_1025_21.
Harvard
Rezaeinasab, R., Jafari, E. and Khodarahmi, G. (2022) 'Quinazolinone-based hybrids with diverse biological activities', Journal of Research in Medical Sciences, 27(1), pp. 68. doi:10.4103/jrms.jrms_1025_21.
Vancouver
Rezaeinasab R, Jafari E, Khodarahmi G. Quinazolinone-based hybrids with diverse biological activities. Journal of Research in Medical Sciences. 2022;27(1):68. doi:10.4103/jrms.jrms_1025_21
IEEE
R. Rezaeinasab, E. Jafari, and G. Khodarahmi, "Quinazolinone-based hybrids with diverse biological activities," Journal of Research in Medical Sciences, vol. 27, no. 1, pp. 68, 2022, doi: 10.4103/jrms.jrms_1025_21.