Abstract
Objectives: COVID-19 associated coagulopathy and prophylactic anticoagulant therapy (PAT) are ongoing topics globally. Using PAT for anti-inflammatory effect may prevent thromboembolic events (TEEs). The objective of this study was to determine the anti-inflammatory effects of PAT in hospitalized COVID-19 patients. Methods: We conducted a retrospective observational study in a tertiary pandemic hospital. Patients were divided into two categories according to their PAT therapy status (PAT (+) and PAT (-)) and into three categories according to clinical features (mild: group 1; moderate: group: 2; and severe: group 3). We then evaluated laboratory parameters and clinical courses. Results: We included 662 hospitalized COVID-19 patients in this study. Enoxaparin sodium was given to all patients as PAT therapy. TEE was developed in five patients in the PAT (+) group. Pulmonary embolism developed in 3/5 patients and deep venous thrombosis in 2/5 patients. Disseminated intravascular coagulation (DIC) was detected in 54 patients in group 3. No statistically significant difference was found in 28-day mortality, development of DIC rates, intubation rates, and TEEs. Conclusions: The use of PAT in critically ill patients was not effective in reducing C-reactive protein, which is one of the biomarkers of inflammation.
Keywords
Publication details
- DOI
- 10.5001/omj.2022.77
- Journal
- Oman Medical Journal
- Publisher
- Oman Medical Specialty Board
- Open access
- Gold open access
Cite this article
APA 7
Alkan, S., Şener, A., Doğan, E., Yüksel, C., & Yüksel, B. (2022). Prophylactic Anticoagulant Treatment Might Have an Anti-inflammatory Effect and Reduce Mortality Rates in Hospitalized COVID-19 Patients? Oman Medical Journal. https://doi.org/10.5001/omj.2022.77
MLA 9
Alkan, Sevil, et al. "Prophylactic Anticoagulant Treatment Might Have an Anti-inflammatory Effect and Reduce Mortality Rates in Hospitalized COVID-19 Patients?" Oman Medical Journal, 2022. https://doi.org/10.5001/omj.2022.77.
Chicago (author–date)
Alkan, Sevil, Alper Şener, Ebru Doğan, Cihan Yüksel, and Buse Yüksel. 2022. "Prophylactic Anticoagulant Treatment Might Have an Anti-inflammatory Effect and Reduce Mortality Rates in Hospitalized COVID-19 Patients?" Oman Medical Journal. https://doi.org/10.5001/omj.2022.77.
Harvard
Alkan, S., Şener, A., Doğan, E., Yüksel, C. and Yüksel, B. (2022) 'Prophylactic Anticoagulant Treatment Might Have an Anti-inflammatory Effect and Reduce Mortality Rates in Hospitalized COVID-19 Patients?', Oman Medical Journal. doi:10.5001/omj.2022.77.
Vancouver
Alkan S, Şener A, Doğan E, Yüksel C, Yüksel B. Prophylactic Anticoagulant Treatment Might Have an Anti-inflammatory Effect and Reduce Mortality Rates in Hospitalized COVID-19 Patients? Oman Medical Journal. 2022. doi:10.5001/omj.2022.77
IEEE
S. Alkan, A. Şener, E. Doğan, C. Yüksel, and B. Yüksel, "Prophylactic Anticoagulant Treatment Might Have an Anti-inflammatory Effect and Reduce Mortality Rates in Hospitalized COVID-19 Patients?," Oman Medical Journal, 2022, doi: 10.5001/omj.2022.77.