Abstract
Epithelioid haemangioendothelioma (EHE) is a rare vascular sarcoma of intermediate malignancy. In 2023, a 31-year-old female presented to a tertiary care hospital in Muscat, Oman, with symptoms later diagnosed as primary vaginal EHE. The patient had primary, locally invasive vaginal EHE that subsequently metastasised to the lungs. The patient experienced progression of systemic disease despite chemotherapy and was therefore transitioned to palliative chemotherapy. The clinical, radiological and histopathological findings as well as the diagnostic features that distinguish EHE from its aggressive mimic, epithelioid angiosarcoma, are described in this report. This case highlights the diagnostic challenges, the importance of molecular confirmation and the unpredictable clinical course of this ultra-rare malignancy. To the best of the authors' knowledge, this is the first reported case of primary vaginal EHE.
Publication details
- DOI
- 10.18295/2075-0528.2982
- Journal
- Sultan Qaboos University Medical Journal, 26(1), 259-265
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY-ND 4.0
Cite this article
APA 7
Al Shuaili, A., Kashoob, H., Niaz, Z., Yaqoob, N., Galaal, K. A. J., & Al Mazrouai, R. A. (2026). Primary Vaginal Epithelioid Haemangioendothelioma with Pulmonary Metastasis: A case report and review of the literature. Sultan Qaboos University Medical Journal, 26(1), 259-265. https://doi.org/10.18295/2075-0528.2982
MLA 9
Al Shuaili, Anwar, et al. "Primary Vaginal Epithelioid Haemangioendothelioma with Pulmonary Metastasis: A case report and review of the literature." Sultan Qaboos University Medical Journal, vol. 26, no. 1, 2026, pp. 259-265. https://doi.org/10.18295/2075-0528.2982.
Chicago (author–date)
Al Shuaili, Anwar, Huda Kashoob, Zahida Niaz, Nausheen Yaqoob, Khadhra Ahmed J. Galaal, and Reem Ahmed Al Mazrouai. 2026. "Primary Vaginal Epithelioid Haemangioendothelioma with Pulmonary Metastasis: A case report and review of the literature." Sultan Qaboos University Medical Journal 26 (1): 259-265. https://doi.org/10.18295/2075-0528.2982.
Harvard
Al Shuaili, A., Kashoob, H., Niaz, Z., Yaqoob, N., Galaal, K. A. J. and Al Mazrouai, R. A. (2026) 'Primary Vaginal Epithelioid Haemangioendothelioma with Pulmonary Metastasis: A case report and review of the literature', Sultan Qaboos University Medical Journal, 26(1), pp. 259-265. doi:10.18295/2075-0528.2982.
Vancouver
Al Shuaili A, Kashoob H, Niaz Z, Yaqoob N, Galaal KAJ, Al Mazrouai RA. Primary Vaginal Epithelioid Haemangioendothelioma with Pulmonary Metastasis: A case report and review of the literature. Sultan Qaboos University Medical Journal. 2026;26(1):259-265. doi:10.18295/2075-0528.2982
IEEE
A. Al Shuaili, H. Kashoob, Z. Niaz, N. Yaqoob, K. A. J. Galaal, and R. A. Al Mazrouai, "Primary Vaginal Epithelioid Haemangioendothelioma with Pulmonary Metastasis: A case report and review of the literature," Sultan Qaboos University Medical Journal, vol. 26, no. 1, pp. 259-265, 2026, doi: 10.18295/2075-0528.2982.