Abstract
Objectives: This study aimed to establish lactate dehydrogenase (LDH) and β-glucuronidase as salivary biomarkers of periodontitis among smokers and non-smokers. Methods: This cross-sectional case-control study was conducted at the Aligarh Muslim University, Aligarh, India, between January and June 2017. A total of 200 participants were divided into four groups based on their periodontal and smoking statuses. Unstimulated mixed saliva samples were collected to estimate LDH and β-glucuronidase levels. In addition, total protein was estimated using Lowry’s method. Results: There was a significant increase in enzyme activity in the periodontitis groups compared to the non-periodontitis groups (P <0.001). However, significantly lower enzyme activity was observed among smokers, irrespective of periodontal status (P <0.001). Nevertheless, a receiver operating characteristic curve analysis indicated the diagnostic potential of both enzymes to be fair-to-excellent. Conclusion: Although smoking was found to significantly alter enzyme activity, LDH and β-glucuronidase were reliable salivary biomarkers of periodontitis among both smokers and non-smokers.
Publication details
- DOI
- 10.18295/squmj.2018.18.03.009
- Journal
- Sultan Qaboos University Medical Journal, 18(3), e318-323
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY-ND 4.0
Cite this article
APA 7
Ali, S. A., Telgi, R. L., Tantry, A., Q., I., & Aleem, A. (2025). Lactate Dehydrogenase and β-Glucuronidase as Salivary Biochemical Markers of Periodontitis Among Smokers and Non-Smokers. Sultan Qaboos University Medical Journal, 18(3), e318-323. https://doi.org/10.18295/squmj.2018.18.03.009
MLA 9
Ali, Syed A., et al. "Lactate Dehydrogenase and β-Glucuronidase as Salivary Biochemical Markers of Periodontitis Among Smokers and Non-Smokers." Sultan Qaboos University Medical Journal, vol. 18, no. 3, 2025, pp. e318-323. https://doi.org/10.18295/squmj.2018.18.03.009.
Chicago (author–date)
Ali, Syed A., Ravi L. Telgi, Amit Tantry, Irfan Q., and Abdul Aleem. 2025. "Lactate Dehydrogenase and β-Glucuronidase as Salivary Biochemical Markers of Periodontitis Among Smokers and Non-Smokers." Sultan Qaboos University Medical Journal 18 (3): e318-323. https://doi.org/10.18295/squmj.2018.18.03.009.
Harvard
Ali, S. A., Telgi, R. L., Tantry, A., Q., I. and Aleem, A. (2025) 'Lactate Dehydrogenase and β-Glucuronidase as Salivary Biochemical Markers of Periodontitis Among Smokers and Non-Smokers', Sultan Qaboos University Medical Journal, 18(3), pp. e318-323. doi:10.18295/squmj.2018.18.03.009.
Vancouver
Ali SA, Telgi RL, Tantry A, Q. I, Aleem A. Lactate Dehydrogenase and β-Glucuronidase as Salivary Biochemical Markers of Periodontitis Among Smokers and Non-Smokers. Sultan Qaboos University Medical Journal. 2025;18(3):e318-323. doi:10.18295/squmj.2018.18.03.009
IEEE
S. A. Ali, R. L. Telgi, A. Tantry, I. Q., and A. Aleem, "Lactate Dehydrogenase and β-Glucuronidase as Salivary Biochemical Markers of Periodontitis Among Smokers and Non-Smokers," Sultan Qaboos University Medical Journal, vol. 18, no. 3, pp. e318-323, 2025, doi: 10.18295/squmj.2018.18.03.009.