Abstract
Immunotherapy with T cells expressing chimeric antigen receptors (CAR) is being evaluated as a potential treatment for B-cell neoplasms. In recent clinical trials it has shown promising results. As the number of potential candidate antigens expands, the choice of suitable target antigens becomes more challenging to design studies and to assess optimal efficacy of CAR. Careful evaluation of candidate target antigens is required to ensure that T cells expressing CAR will preferentially kill malignant cells with a minimal toxicity against normal tissues. B cells express specific surface antigens that can theoretically act as targets for CAR design. Although many of these antigens can stimulate effective cellular immune responses in vivo, their implementation in clinical settings remains a challenge. Only targeted B-cell antigens CD19 and CD20 have been tested in clinical trials. This article reviews exploitable B cell surface antigens for CAR design and examines obstacles that could interfere with the identification of potentially useful cellular targets.
Publication details
- DOI
- 10.18295/2075-0528.1377
- Journal
- Sultan Qaboos University Medical Journal, 12(3), 273-285
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY-ND 4.0
Cite this article
APA 7
Boulassel, M. R., & Galal, A. (2025). Immunotherapy for B-Cell Neoplasms using T Cells expressing Chimeric Antigen Receptors: From antigen choice to clinical implementation. Sultan Qaboos University Medical Journal, 12(3), 273-285. https://doi.org/10.18295/2075-0528.1377
MLA 9
Boulassel, Mohamed Rachid, and Ahmed Galal. "Immunotherapy for B-Cell Neoplasms using T Cells expressing Chimeric Antigen Receptors: From antigen choice to clinical implementation." Sultan Qaboos University Medical Journal, vol. 12, no. 3, 2025, pp. 273-285. https://doi.org/10.18295/2075-0528.1377.
Chicago (author–date)
Boulassel, Mohamed Rachid, and Ahmed Galal. 2025. "Immunotherapy for B-Cell Neoplasms using T Cells expressing Chimeric Antigen Receptors: From antigen choice to clinical implementation." Sultan Qaboos University Medical Journal 12 (3): 273-285. https://doi.org/10.18295/2075-0528.1377.
Harvard
Boulassel, M. R. and Galal, A. (2025) 'Immunotherapy for B-Cell Neoplasms using T Cells expressing Chimeric Antigen Receptors: From antigen choice to clinical implementation', Sultan Qaboos University Medical Journal, 12(3), pp. 273-285. doi:10.18295/2075-0528.1377.
Vancouver
Boulassel MR, Galal A. Immunotherapy for B-Cell Neoplasms using T Cells expressing Chimeric Antigen Receptors: From antigen choice to clinical implementation. Sultan Qaboos University Medical Journal. 2025;12(3):273-285. doi:10.18295/2075-0528.1377
IEEE
M. R. Boulassel, and A. Galal, "Immunotherapy for B-Cell Neoplasms using T Cells expressing Chimeric Antigen Receptors: From antigen choice to clinical implementation," Sultan Qaboos University Medical Journal, vol. 12, no. 3, pp. 273-285, 2025, doi: 10.18295/2075-0528.1377.