Abstract
Objectives: Ameloblastoma, comprising approximately 11% of all odontogenic tumors, is a locally aggressive tumor with a high recurrence rate. This study aimed to assess the immunohistochemical expression of Ki-67 and p53 and their association with clinical and pathological factors among patients with ameloblastoma. Methods: Retrospective follow-up data of patients histologically confirmed with ameloblastoma at Makerere College of Health Sciences in Kampala, Uganda from January 2012 to December 2018 were retrieved. Factors associated with Ki-67 and p53 immunohistochemical expression were determined using one-way analysis of variance. Chi-square and Fisher’s exact statistical tests were used to assess factors associated with recurrence. A two-tailed p < 0.05 was considered statistically significant. Results: A total of 40 patients confirmed histologically with ameloblastoma were included in the analysis. The majority (62.5%) of cases were of the conventional type of ameloblastoma. The expressions of Ki-67 and p53 were 52.5% and 85.0%, respectively. Recurrence was found in 47.5% of patients and it was associated with conventional histological type (p = 0.042), segmental resection (p < 0.001), tumor size (p < 0.001), and high p53 expression (p = 0.041). Conclusions: Almost half the cases in this study had recurrence. The immunohistochemical expression of p53 was significantly higher than that of Ki-67.
Keywords
Publication details
- DOI
- 10.5001/omj.2024.55
- Journal
- Oman Medical Journal
- Publisher
- Oman Medical Specialty Board
- Open access
- Gold open access
Cite this article
APA 7
Yahaya, J. J., Bwambale, P., Morgan, E. D., Abraham, Z. S., Owor, G., & Wabinga, H. (2024). Immunohistochemical Expression of Ki-67 and p53 and Their Prognostic Role in Ameloblastoma: A Longitudinal Study. Oman Medical Journal. https://doi.org/10.5001/omj.2024.55
MLA 9
Yahaya, James J., et al. "Immunohistochemical Expression of Ki-67 and p53 and Their Prognostic Role in Ameloblastoma: A Longitudinal Study." Oman Medical Journal, 2024. https://doi.org/10.5001/omj.2024.55.
Chicago (author–date)
Yahaya, James J., Phenehas Bwambale, Emmanuel D. Morgan, Zephania S. Abraham, Gelardine Owor, and Henry Wabinga. 2024. "Immunohistochemical Expression of Ki-67 and p53 and Their Prognostic Role in Ameloblastoma: A Longitudinal Study." Oman Medical Journal. https://doi.org/10.5001/omj.2024.55.
Harvard
Yahaya, J. J., Bwambale, P., Morgan, E. D., Abraham, Z. S., Owor, G. and Wabinga, H. (2024) 'Immunohistochemical Expression of Ki-67 and p53 and Their Prognostic Role in Ameloblastoma: A Longitudinal Study', Oman Medical Journal. doi:10.5001/omj.2024.55.
Vancouver
Yahaya JJ, Bwambale P, Morgan ED, Abraham ZS, Owor G, Wabinga H. Immunohistochemical Expression of Ki-67 and p53 and Their Prognostic Role in Ameloblastoma: A Longitudinal Study. Oman Medical Journal. 2024. doi:10.5001/omj.2024.55
IEEE
J. J. Yahaya, P. Bwambale, E. D. Morgan, Z. S. Abraham, G. Owor, and H. Wabinga, "Immunohistochemical Expression of Ki-67 and p53 and Their Prognostic Role in Ameloblastoma: A Longitudinal Study," Oman Medical Journal, 2024, doi: 10.5001/omj.2024.55.