Abstract
Objectives: To evaluate the immunohistochemical expression of estrogen receptors (ER) and progesterone receptors (PR) in colorectal adenoma and adenocarcinoma and to correlate this immunohistochemical expression with different clinicopathological parameters. Methods: The study was retrospectively designed. A total of 86 tissue samples, including 33 paraffin blocks from patients with colorectal adenomas, 33 paraffin blocks from patients with colorectal adenocarcinomas and a control group of 20 samples of non-tumorous colonic tissue, were included in the study. Results: The frequency of expression of ER and PR showed a gradual increase from control through adenoma to carcinoma. The frequencies of expression of ER in the control, adenoma and carcinoma were (10%, 15.15% and 42.42% respectively, p <0.001), while the frequency of expression for PR were (10%, 24.24% and 36.36% respectively, p <0.001). Strong ER and PR staining was mainly seen in carcinoma cases (42.42%, 36.36%, respectively) in comparison with adenoma (9.09%, 15.15%, respectively) and control (0%, 0%, respectively). The three digital parameters of ER and PR immunohistochemical expression (Area [A], Number of objects [N], and intensity [I]) were significantly increased in a sequence of normal mucosa-adenoma-carcinoma. There was a significant positive correlation between ER and PR in adenoma (r=0.312, p=0.034) and carcinoma (r=0.321, p=0.0398). Conclusion: ER and PR expression increased in a sequence of; normal colonic mucosa-adenoma-carcinoma, and a positive correlation was observed between ER and PR expression in colonic adenoma and carcinoma specimen indicating that ER and PR may play a role in colorectal carcinogenesis.
Keywords
Publication details
- DOI
- 10.5001/omj.2011.78
- Journal
- Oman Medical Journal
- Publisher
- Oman Medical Specialty Board
- Open access
- Gold open access
Cite this article
APA 7
Qasim, B. J., Ali, H. H., & Hussein, A. G. (2011). Immunohistochemical Expression of Estrogen and Progesterone Receptors in Human Colorectal Adenoma and Carcinoma Using Specified Automated Cellular Image Analysis System: A Clinicopathological Study. Oman Medical Journal. https://doi.org/10.5001/omj.2011.78
MLA 9
Qasim, Ban Jumaa, et al. "Immunohistochemical Expression of Estrogen and Progesterone Receptors in Human Colorectal Adenoma and Carcinoma Using Specified Automated Cellular Image Analysis System: A Clinicopathological Study." Oman Medical Journal, 2011. https://doi.org/10.5001/omj.2011.78.
Chicago (author–date)
Qasim, Ban Jumaa, Hussam Hasson Ali, and Alaa Ghani Hussein. 2011. "Immunohistochemical Expression of Estrogen and Progesterone Receptors in Human Colorectal Adenoma and Carcinoma Using Specified Automated Cellular Image Analysis System: A Clinicopathological Study." Oman Medical Journal. https://doi.org/10.5001/omj.2011.78.
Harvard
Qasim, B. J., Ali, H. H. and Hussein, A. G. (2011) 'Immunohistochemical Expression of Estrogen and Progesterone Receptors in Human Colorectal Adenoma and Carcinoma Using Specified Automated Cellular Image Analysis System: A Clinicopathological Study', Oman Medical Journal. doi:10.5001/omj.2011.78.
Vancouver
Qasim BJ, Ali HH, Hussein AG. Immunohistochemical Expression of Estrogen and Progesterone Receptors in Human Colorectal Adenoma and Carcinoma Using Specified Automated Cellular Image Analysis System: A Clinicopathological Study. Oman Medical Journal. 2011. doi:10.5001/omj.2011.78
IEEE
B. J. Qasim, H. H. Ali, and A. G. Hussein, "Immunohistochemical Expression of Estrogen and Progesterone Receptors in Human Colorectal Adenoma and Carcinoma Using Specified Automated Cellular Image Analysis System: A Clinicopathological Study," Oman Medical Journal, 2011, doi: 10.5001/omj.2011.78.