Abstract
The majority of hemolytic disease of the fetus and newborn (HDFN) reported in the literature is due to ABO and rhesus incompatibility. However, there are also other minor blood groups that have been identified as a cause of HDFN, although the occurrence is much rarer. The antibody screening program for D negative mother and the anti-D immunoglobulin treatment showed a significant reduction of the occurrence of HDFN secondary to anti-D. In a developed country, the screening for red blood cell antibody in the pregnant mother other than anti-D reduced the possibility of HDFN occurrence hence reduced the fetal morbidity and subsequently increased the fetal well being during pregnancy and after the postnatal period. In this case report, we discuss HDFN in a primigravida patient secondary to multiple alloantibodies (anti-Jk a and anti-E). The baby developed jaundice with bilirubin levels approaching the exchange transfusion level. However, with extensive phototherapy and immunoglobulin treatment, the child did not require exchange transfusion. We also included the importance of the routine antenatal antibody screening program. This practice will help the transfusion center to find the antigen negative blood in a timely manner and reduce the morbidities and mortalities of HDFN among the newborns.
Keywords
Publication details
- DOI
- 10.5001/omj.2020.135
- Journal
- Oman Medical Journal
- Publisher
- Oman Medical Specialty Board
- Open access
- Gold open access
Cite this article
APA 7
Iberahim, S., Aizuddin, M. J., Kadir, N. A., Rameli, N., Adzahar, S., Noor, N. H. M., & Abdullah, W. Z. (2020). Hemolytic Disease of Fetus and Newborn in a Primigravida with Multiple Alloantibodies Involving Anti-Jk a and Anti-E: A Case Report. Oman Medical Journal. https://doi.org/10.5001/omj.2020.135
MLA 9
Iberahim, Salfarina, et al. "Hemolytic Disease of Fetus and Newborn in a Primigravida with Multiple Alloantibodies Involving Anti-Jk a and Anti-E: A Case Report." Oman Medical Journal, 2020. https://doi.org/10.5001/omj.2020.135.
Chicago (author–date)
Iberahim, Salfarina, Maryam Jameelah Aizuddin, Nurulhuda Abd Kadir, Nabilah Rameli, Sumaiyah Adzahar, Noor Haslina Mohd Noor, and Wan Zaidah Abdullah. 2020. "Hemolytic Disease of Fetus and Newborn in a Primigravida with Multiple Alloantibodies Involving Anti-Jk a and Anti-E: A Case Report." Oman Medical Journal. https://doi.org/10.5001/omj.2020.135.
Harvard
Iberahim, S., Aizuddin, M. J., Kadir, N. A., Rameli, N., Adzahar, S., Noor, N. H. M. and Abdullah, W. Z. (2020) 'Hemolytic Disease of Fetus and Newborn in a Primigravida with Multiple Alloantibodies Involving Anti-Jk a and Anti-E: A Case Report', Oman Medical Journal. doi:10.5001/omj.2020.135.
Vancouver
Iberahim S, Aizuddin MJ, Kadir NA, Rameli N, Adzahar S, Noor NHM, et al. Hemolytic Disease of Fetus and Newborn in a Primigravida with Multiple Alloantibodies Involving Anti-Jk a and Anti-E: A Case Report. Oman Medical Journal. 2020. doi:10.5001/omj.2020.135
IEEE
S. Iberahim, M. J. Aizuddin, N. A. Kadir, N. Rameli, S. Adzahar, N. H. M. Noor, and W. Z. Abdullah, "Hemolytic Disease of Fetus and Newborn in a Primigravida with Multiple Alloantibodies Involving Anti-Jk a and Anti-E: A Case Report," Oman Medical Journal, 2020, doi: 10.5001/omj.2020.135.