Abstract
Objectives: Nephrotic syndrome (NS) is considered as a major global health concern, and a higher proportion of children with NS have steroid resistance (SR). This study aimed to assess the health-related quality of life (HRQoL) of children with SRNS. Methods: This case-control study was conducted from January to June 2023 at University Children’s Hospital, Minia, Egypt. There were 160 participants in total who were divided into 3 groups: 60 participants with SRNS and 2 control groups (one of which had steroid-sensitive NS) that were matched appropriately. Each participant’s QoL was assessed using the Pediatric Quality of Life Inventory (PedsQL 4.0 Generic Core Scales). Results: Children with SRNS had the lowest mean scores across all domains of the PedsQL (P<0.001) with duration of the illness and high cumulative glucocorticoids being significant in the prediction of low QoL in those children (P = 0.01 each). Conclusions: To properly evaluate and improve the QoL for children with SRNS, coordinated efforts involving paediatric nephrologists and psychiatrists are required.
Publication details
- DOI
- 10.18295/2075-0528.2892
- Journal
- Sultan Qaboos University Medical Journal, 25(1), 641-649
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY-ND 4.0
Cite this article
APA 7
Mahgoob, M., & Ali, M. W. (2025). Health-Related Quality of Life in Children with Steroid-Resistant Nephrotic Syndrome. Sultan Qaboos University Medical Journal, 25(1), 641-649. https://doi.org/10.18295/2075-0528.2892
MLA 9
Mahgoob, Mohamed, and Marwa W.E. Ali. "Health-Related Quality of Life in Children with Steroid-Resistant Nephrotic Syndrome." Sultan Qaboos University Medical Journal, vol. 25, no. 1, 2025, pp. 641-649. https://doi.org/10.18295/2075-0528.2892.
Chicago (author–date)
Mahgoob, Mohamed, and Marwa W.E. Ali. 2025. "Health-Related Quality of Life in Children with Steroid-Resistant Nephrotic Syndrome." Sultan Qaboos University Medical Journal 25 (1): 641-649. https://doi.org/10.18295/2075-0528.2892.
Harvard
Mahgoob, M. and Ali, M. W. (2025) 'Health-Related Quality of Life in Children with Steroid-Resistant Nephrotic Syndrome', Sultan Qaboos University Medical Journal, 25(1), pp. 641-649. doi:10.18295/2075-0528.2892.
Vancouver
Mahgoob M, Ali MW. Health-Related Quality of Life in Children with Steroid-Resistant Nephrotic Syndrome. Sultan Qaboos University Medical Journal. 2025;25(1):641-649. doi:10.18295/2075-0528.2892
IEEE
M. Mahgoob, and M. W. Ali, "Health-Related Quality of Life in Children with Steroid-Resistant Nephrotic Syndrome," Sultan Qaboos University Medical Journal, vol. 25, no. 1, pp. 641-649, 2025, doi: 10.18295/2075-0528.2892.