Abstract
We report here four cases of genital ulcers that developed after the administration of all-trans retinoic acid (ATRA) for the treatment of acute promyelocytic leukemia (APL). Between October 2007 and March 2010, three males and one female (age range 19-35 years) were identified to have genital ulcers after being prescribed all-trans retinoic acid (ATRA) as a part of chemotherapy for APL. This is the first series of cases describing genital ulcers, as a unique and rare complication of ATRA used for treatment of APL in these patients, with no other cause identified. Following temporary cessation of ATRA for a few days in these three cases, improvement of the ulcers was noted.
Keywords
Publication details
- DOI
- 10.5001/omj.2013.56
- Journal
- Oman Medical Journal
- Publisher
- Oman Medical Specialty Board
- Open access
- Gold open access
Cite this article
APA 7
Al-Huneini, M., Wasim, F., Al-Farsi, K., Al-Khabori, M., & Al Kindi, S. (2013). Genital Ulcer Development in Patients with Acute Promyelocytic Leukaemia Treated with All-Trans Retinoic Acid: A Case Series. Oman Medical Journal. https://doi.org/10.5001/omj.2013.56
MLA 9
Al-Huneini, Mohammed, et al. "Genital Ulcer Development in Patients with Acute Promyelocytic Leukaemia Treated with All-Trans Retinoic Acid: A Case Series." Oman Medical Journal, 2013. https://doi.org/10.5001/omj.2013.56.
Chicago (author–date)
Al-Huneini, Mohammed, Fauzia Wasim, Khalil Al-Farsi, Murtadha Al-Khabori, and Salam Al Kindi. 2013. "Genital Ulcer Development in Patients with Acute Promyelocytic Leukaemia Treated with All-Trans Retinoic Acid: A Case Series." Oman Medical Journal. https://doi.org/10.5001/omj.2013.56.
Harvard
Al-Huneini, M., Wasim, F., Al-Farsi, K., Al-Khabori, M. and Al Kindi, S. (2013) 'Genital Ulcer Development in Patients with Acute Promyelocytic Leukaemia Treated with All-Trans Retinoic Acid: A Case Series', Oman Medical Journal. doi:10.5001/omj.2013.56.
Vancouver
Al-Huneini M, Wasim F, Al-Farsi K, Al-Khabori M, Al Kindi S. Genital Ulcer Development in Patients with Acute Promyelocytic Leukaemia Treated with All-Trans Retinoic Acid: A Case Series. Oman Medical Journal. 2013. doi:10.5001/omj.2013.56
IEEE
M. Al-Huneini, F. Wasim, K. Al-Farsi, M. Al-Khabori, and S. Al Kindi, "Genital Ulcer Development in Patients with Acute Promyelocytic Leukaemia Treated with All-Trans Retinoic Acid: A Case Series," Oman Medical Journal, 2013, doi: 10.5001/omj.2013.56.