Abstract
Keratoconus (KC) is the most common ectasia of the cornea and is a common reason for corneal transplant. Therapeutic strategies that can arrest the progression of this disease and modify the underlying pathogenesis are getting more and more popularity among scientists. Cumulating data represent strong evidence of a genetic role in the pathogenesis of KC. Different loci have been identified, and certain mutations have also been mapped for this disease. Moreover, Biophysical properties of the cornea create an appropriate candidate of this tissue for gene therapy. Immune privilege, transparency and ex vivo stability are among these properties. Recent advantage in vectors, besides the ability to modulate the corneal milieu for accepting the target gene for a longer period and fruitful translation, make a big hope for stupendous results reasonable.
Keywords
Publication details
- DOI
- 10.4103/0974-620x.149854
- Journal
- Oman Journal of Ophthalmology, 8(1), 3-8
- Publisher
- Medknow Publications
- Open access
- Gold open access
Cite this article
APA 7
Farjadnia, M., Naderan, M., & Mohammadpour, M. (2015). Gene therapy in keratoconus. Oman Journal of Ophthalmology, 8(1), 3-8. https://doi.org/10.4103/0974-620x.149854
MLA 9
Farjadnia, Mahgol, et al. "Gene therapy in keratoconus." Oman Journal of Ophthalmology, vol. 8, no. 1, 2015, pp. 3-8. https://doi.org/10.4103/0974-620x.149854.
Chicago (author–date)
Farjadnia, Mahgol, Mohammad Naderan, and Mehrdad Mohammadpour. 2015. "Gene therapy in keratoconus." Oman Journal of Ophthalmology 8 (1): 3-8. https://doi.org/10.4103/0974-620x.149854.
Harvard
Farjadnia, M., Naderan, M. and Mohammadpour, M. (2015) 'Gene therapy in keratoconus', Oman Journal of Ophthalmology, 8(1), pp. 3-8. doi:10.4103/0974-620x.149854.
Vancouver
Farjadnia M, Naderan M, Mohammadpour M. Gene therapy in keratoconus. Oman Journal of Ophthalmology. 2015;8(1):3-8. doi:10.4103/0974-620x.149854
IEEE
M. Farjadnia, M. Naderan, and M. Mohammadpour, "Gene therapy in keratoconus," Oman Journal of Ophthalmology, vol. 8, no. 1, pp. 3-8, 2015, doi: 10.4103/0974-620x.149854.