Abstract
Objectives: In Oman, many hypertensive patients with a family history of the disease respond to treatment with spironolactone, a mineralocorticoid receptor (MC-R) blocking agent thus suggesting a high prevalence of mineralocorticoid (MC) induced disease. The aim of this study was to document the prevalence of MC induced disease in patients with a positive family history of hypertension (HTN). Methods: Serum calcium, potassium, creatinine, aldosterone and renin levels were measured under standard conditions in all patients together with an abdominal ultrasound scan and an adrenal computed tomography (CT) scan in four patients. Results: In this small study, we show that 18 of the 27 patients (66%) had undetectable (suppressed) renin levels with usually normal aldosterone values (14 patients) and respond to treatment with spironoactone. Conclusion: We suggest that MC induced hypertension is likely to be common in the Middle East. In evolutionary terms, this makes sense as the ability to conserve salt in hot climates might be expected to confer a definite survival advantage.
Publication details
- DOI
- 10.18295/2075-0528.2713
- Journal
- Sultan Qaboos University Medical Journal, 8(2), 165-169
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY-ND 4.0
Cite this article
APA 7
Woodhouse, N. J., El-Shafie, O. T., Ben Doi, F., & A., S. (2025). Familial Mineralocorticoid Induced Hypertension in the Sultanate of Oman. Sultan Qaboos University Medical Journal, 8(2), 165-169. https://doi.org/10.18295/2075-0528.2713
MLA 9
Woodhouse, Nicholas JY, et al. "Familial Mineralocorticoid Induced Hypertension in the Sultanate of Oman." Sultan Qaboos University Medical Journal, vol. 8, no. 2, 2025, pp. 165-169. https://doi.org/10.18295/2075-0528.2713.
Chicago (author–date)
Woodhouse, Nicholas JY, Omayma T. El-Shafie, Fatma Ben Doi, and Suhail A. 2025. "Familial Mineralocorticoid Induced Hypertension in the Sultanate of Oman." Sultan Qaboos University Medical Journal 8 (2): 165-169. https://doi.org/10.18295/2075-0528.2713.
Harvard
Woodhouse, N. J., El-Shafie, O. T., Ben Doi, F. and A., S. (2025) 'Familial Mineralocorticoid Induced Hypertension in the Sultanate of Oman', Sultan Qaboos University Medical Journal, 8(2), pp. 165-169. doi:10.18295/2075-0528.2713.
Vancouver
Woodhouse NJ, El-Shafie OT, Ben Doi F, A. S. Familial Mineralocorticoid Induced Hypertension in the Sultanate of Oman. Sultan Qaboos University Medical Journal. 2025;8(2):165-169. doi:10.18295/2075-0528.2713
IEEE
N. J. Woodhouse, O. T. El-Shafie, F. Ben Doi, and S. A., "Familial Mineralocorticoid Induced Hypertension in the Sultanate of Oman," Sultan Qaboos University Medical Journal, vol. 8, no. 2, pp. 165-169, 2025, doi: 10.18295/2075-0528.2713.