Abstract
Extracting patient-specific vascular trees from volumetric medical images is fundamental to computational angiography and non-invasive hemodynamic assessment. Conventional voxel segmentation models often sever delicate bifurcations, while heuristic Euclidean Minimum Spanning Trees introduce non-anatomical shortcuts. Moreover, linear Poiseuille flow neglects quadratic kinetic dissipation across arterial narrowings, underestimating ischemia. We formulate an end-to-end framework decoupling continuous geometric arborescence generation from non-linear hemodynamics. First, an autonomous 3D Ostium Landmark Localization Head with dual-sinus query channels and spherical-gated refinement eliminates centerline seeding dependency, achieving cohort mean localization error of 7.63 mm (7.43 mm LCA, 7.83 mm RCA; 71.4% <= 8.0 mm) from raw contrast context. Second, a Spatially-Grounded Deformable Step Flow Architecture queries continuous 3D feature pyramids via trilinear sampling, sequentially generating trajectories with anchor boundary enforcement (X(0) = P_start). Third, a Top-Down Recursive Arborescence State Machine detects bifurcation peaks via Tree-NMS and parameterizes predecessor parent pointers (p_k < k), guaranteeing single connected acyclic tree topology (beta_0 = 1, beta_1 = 0) with differentiable step termination. Fourth, an iterative Picard non-linear Kirchhoff solver with Young-Tsai / Gould quadratic dissipation enforces machine-precision mass conservation (residual 5.82e-11 mL/s). Across 14 development patients under standardized in-silico stenosis stress testing (Q_0 = 4.0 mL/s), linear Poiseuille flow misclassifies 75% diameter lesions as non-ischemic (FFR > 0.80) in 14/14 cases, whereas our non-linear solver captures functional ischemia (FFR = 0.5864, lesion disparity 32.89 mmHg, p = 6.10e-5) with 3.66x collateral shunting. Test set firewall isolation was maintained.
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Cite this article
APA 7
Jia, Z., & Ming, X. (2026). End-to-End Autonomous Recursive Arborescence Deformable Flow and Non-Linear Hemodynamics for Patient-Specific Coronary Centerline Extraction. https://omanscience.com/en/articles/end-to-end-autonomous-recursive-arborescence-deformable-flow-and-non-linear-hemodynamics-for-patient-specific-coronary-centerline-extraction
MLA 9
Jia, Zeyu, and Xin Ming. "End-to-End Autonomous Recursive Arborescence Deformable Flow and Non-Linear Hemodynamics for Patient-Specific Coronary Centerline Extraction." https://omanscience.com/en/articles/end-to-end-autonomous-recursive-arborescence-deformable-flow-and-non-linear-hemodynamics-for-patient-specific-coronary-centerline-extraction.
Chicago (author–date)
Jia, Zeyu, and Xin Ming. 2026. "End-to-End Autonomous Recursive Arborescence Deformable Flow and Non-Linear Hemodynamics for Patient-Specific Coronary Centerline Extraction." https://omanscience.com/en/articles/end-to-end-autonomous-recursive-arborescence-deformable-flow-and-non-linear-hemodynamics-for-patient-specific-coronary-centerline-extraction.
Harvard
Jia, Z. and Ming, X. (2026) 'End-to-End Autonomous Recursive Arborescence Deformable Flow and Non-Linear Hemodynamics for Patient-Specific Coronary Centerline Extraction', Available at: https://omanscience.com/en/articles/end-to-end-autonomous-recursive-arborescence-deformable-flow-and-non-linear-hemodynamics-for-patient-specific-coronary-centerline-extraction.
Vancouver
Jia Z, Ming X. End-to-End Autonomous Recursive Arborescence Deformable Flow and Non-Linear Hemodynamics for Patient-Specific Coronary Centerline Extraction. https://omanscience.com/en/articles/end-to-end-autonomous-recursive-arborescence-deformable-flow-and-non-linear-hemodynamics-for-patient-specific-coronary-centerline-extraction
IEEE
Z. Jia, and X. Ming, "End-to-End Autonomous Recursive Arborescence Deformable Flow and Non-Linear Hemodynamics for Patient-Specific Coronary Centerline Extraction," https://omanscience.com/en/articles/end-to-end-autonomous-recursive-arborescence-deformable-flow-and-non-linear-hemodynamics-for-patient-specific-coronary-centerline-extraction.