Abstract
Keloids are abnormal fibroproliferative scars with aggressive dermal growth expanding beyond the borders of the original injury. Different therapeutic modalities, such as corticosteroids, surgical excision, topical silicone gel sheeting, laser therapy, cryotherapy, photodynamic therapy and radiotherapy, have been used to treat keloids; however, none of these modalities has proven completely effective. Recently, researchers have devised several promising anti-keloid therapies including anti-hypertensive pharmaceuticals, calcineurin inhibitors, electrical stimulation, mesenchymal stem cell therapy, microneedle physical contact and ribonucleic acid-based therapies. The present review summarises emerging and novel treatments for keloids. PubMed® (National Library of Medicine, Bethesda, Maryland, USA), EMBASE (Elsevier, Amsterdam, Netherlands) and Web of Science (Clarivate Analytics, Philadelphia, Pennsylvania, USA) were searched for relevant literature published between January 1987 to June 2020. A total of 118 articles were included in this review. A deeper understanding of the molecular mechanisms underlying keloid scarring pathogenesis would open further avenues for developing innovative treatments.
Publication details
- DOI
- 10.18295/squmj.2021.21.01.004
- Journal
- Sultan Qaboos University Medical Journal, 21(1), e22-33
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY-ND 4.0
Cite this article
APA 7
Memariani, H., Memariani, M., Moravvej, H., & Shahidi-Dadras, M. (2025). Emerging and Novel Therapies for Keloids: A compendious review. Sultan Qaboos University Medical Journal, 21(1), e22-33. https://doi.org/10.18295/squmj.2021.21.01.004
MLA 9
Memariani, Hamed, et al. "Emerging and Novel Therapies for Keloids: A compendious review." Sultan Qaboos University Medical Journal, vol. 21, no. 1, 2025, pp. e22-33. https://doi.org/10.18295/squmj.2021.21.01.004.
Chicago (author–date)
Memariani, Hamed, Mojtaba Memariani, Hamideh Moravvej, and Mohammad Shahidi-Dadras. 2025. "Emerging and Novel Therapies for Keloids: A compendious review." Sultan Qaboos University Medical Journal 21 (1): e22-33. https://doi.org/10.18295/squmj.2021.21.01.004.
Harvard
Memariani, H., Memariani, M., Moravvej, H. and Shahidi-Dadras, M. (2025) 'Emerging and Novel Therapies for Keloids: A compendious review', Sultan Qaboos University Medical Journal, 21(1), pp. e22-33. doi:10.18295/squmj.2021.21.01.004.
Vancouver
Memariani H, Memariani M, Moravvej H, Shahidi-Dadras M. Emerging and Novel Therapies for Keloids: A compendious review. Sultan Qaboos University Medical Journal. 2025;21(1):e22-33. doi:10.18295/squmj.2021.21.01.004
IEEE
H. Memariani, M. Memariani, H. Moravvej, and M. Shahidi-Dadras, "Emerging and Novel Therapies for Keloids: A compendious review," Sultan Qaboos University Medical Journal, vol. 21, no. 1, pp. e22-33, 2025, doi: 10.18295/squmj.2021.21.01.004.