Abstract
This systematic review and meta-analysis aimed to evaluate the effectiveness of vaginal magnesium sulfate (MgSO4) administration during labour. A comprehensive search was conducted across six databases up to 30 July 2024, and updated on 13 January 2025, with no restrictions on time, language, or geographical region. The risk of bias was assessed using the RoB 2 tool, and the certainty of evidence was evaluated using GRADEpro. A total of seven randomised controlled trials were included. The meta-analysis demonstrated that topical magnesium sulfate significantly increased cervical dilatation by 2.27 cm (95% confidence interval [CI]: 1.98 to 2.56; PPP
Publication details
- DOI
- 10.18295/2075-0528.2885
- Journal
- Sultan Qaboos University Medical Journal, 25(1), 697-707
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY-ND 4.0
Cite this article
APA 7
Makvandi, S., Manouchehri, E., Razi, M., Mofrad, S. A., & Larki, M. (2025). Effectiveness of Vaginal Magnesium Sulfate on Pain and Labor Duration: A systematic review and meta-analysis. Sultan Qaboos University Medical Journal, 25(1), 697-707. https://doi.org/10.18295/2075-0528.2885
MLA 9
Makvandi, Somayeh, et al. "Effectiveness of Vaginal Magnesium Sulfate on Pain and Labor Duration: A systematic review and meta-analysis." Sultan Qaboos University Medical Journal, vol. 25, no. 1, 2025, pp. 697-707. https://doi.org/10.18295/2075-0528.2885.
Chicago (author–date)
Makvandi, Somayeh, Elham Manouchehri, Mahdieh Razi, Samaneh Alinejad Mofrad, and Mona Larki. 2025. "Effectiveness of Vaginal Magnesium Sulfate on Pain and Labor Duration: A systematic review and meta-analysis." Sultan Qaboos University Medical Journal 25 (1): 697-707. https://doi.org/10.18295/2075-0528.2885.
Harvard
Makvandi, S., Manouchehri, E., Razi, M., Mofrad, S. A. and Larki, M. (2025) 'Effectiveness of Vaginal Magnesium Sulfate on Pain and Labor Duration: A systematic review and meta-analysis', Sultan Qaboos University Medical Journal, 25(1), pp. 697-707. doi:10.18295/2075-0528.2885.
Vancouver
Makvandi S, Manouchehri E, Razi M, Mofrad SA, Larki M. Effectiveness of Vaginal Magnesium Sulfate on Pain and Labor Duration: A systematic review and meta-analysis. Sultan Qaboos University Medical Journal. 2025;25(1):697-707. doi:10.18295/2075-0528.2885
IEEE
S. Makvandi, E. Manouchehri, M. Razi, S. A. Mofrad, and M. Larki, "Effectiveness of Vaginal Magnesium Sulfate on Pain and Labor Duration: A systematic review and meta-analysis," Sultan Qaboos University Medical Journal, vol. 25, no. 1, pp. 697-707, 2025, doi: 10.18295/2075-0528.2885.