Abstract
Objectives: This study aimed to evaluate the effectiveness and safety of fingolimod in Omani multiple sclerosis (MS) patients. Fingolimod is one of the oral drugs used to treat MS. However, there is limited information on its effectiveness and safety among the Omani population. Methods: This retrospective real-world study included 65 Omani MS patients who received fingolimod therapy from 2012 to 2021 at a single tertiary centre in Oman. Data were collected between August and November 2021. Various measures were used to evaluate the effectiveness and safety of fingolimod. Results: Out of 65 MS patients included in the study, 51 (79%) were female. The median duration of fingolimod use was 3.6 ± 2.5 years. The results of the last follow-up visit indicate that the median annualised relapse rate decreased by 84% and relapse-free rate (RFR) increased to 90%, with only a minimal (13%) increase in the expanded disability status. The median number of gadolinium-enhanced lesions in the brain and spine decreased significantly by 88% and 67%, respectively, while the new or enlarged T2 lesions in the brain significantly decreased by 62% (P < 0.050) over the treatment period. The most common side effect was bradycardia (32%). Patient age and age at treatment initiation were significant predictors of RFR (P < 0.050). Conclusion: This study suggests that the effectiveness and safety profiles of fingolimod in Omani MS patients are similar to those determined by standard clinical trials and real-world retrospective studies.
Publication details
- DOI
- 10.18295/2075-0528.2829
- Journal
- Sultan Qaboos University Medical Journal, 25(1), 225-232
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY-ND 4.0
Cite this article
APA 7
Al-Hashmi, G. K. H., Al-Asmi, A., Islam, M. M., Al-Zakwani, I., Butt, M., Al Qassabi, A., Al-Abri, H., & Gujjar, A. R. (2025). Effectiveness and Safety Profile of Fingolimod in Treating Omani Patients with Multiple Sclerosis: A single tertiary centre experience. Sultan Qaboos University Medical Journal, 25(1), 225-232. https://doi.org/10.18295/2075-0528.2829
MLA 9
Al-Hashmi, Ghaida K. H., et al. "Effectiveness and Safety Profile of Fingolimod in Treating Omani Patients with Multiple Sclerosis: A single tertiary centre experience." Sultan Qaboos University Medical Journal, vol. 25, no. 1, 2025, pp. 225-232. https://doi.org/10.18295/2075-0528.2829.
Chicago (author–date)
Al-Hashmi, Ghaida K. H., Abdullah Al-Asmi, M. Mazharul Islam, Ibrahim Al-Zakwani, Mehwish Butt, Ahmed Al Qassabi, Haifa Al-Abri, and Arunodaya R. Gujjar. 2025. "Effectiveness and Safety Profile of Fingolimod in Treating Omani Patients with Multiple Sclerosis: A single tertiary centre experience." Sultan Qaboos University Medical Journal 25 (1): 225-232. https://doi.org/10.18295/2075-0528.2829.
Harvard
Al-Hashmi, G. K. H., Al-Asmi, A., Islam, M. M., Al-Zakwani, I., Butt, M., Al Qassabi, A., Al-Abri, H. and Gujjar, A. R. (2025) 'Effectiveness and Safety Profile of Fingolimod in Treating Omani Patients with Multiple Sclerosis: A single tertiary centre experience', Sultan Qaboos University Medical Journal, 25(1), pp. 225-232. doi:10.18295/2075-0528.2829.
Vancouver
Al-Hashmi GKH, Al-Asmi A, Islam MM, Al-Zakwani I, Butt M, Al Qassabi A, et al. Effectiveness and Safety Profile of Fingolimod in Treating Omani Patients with Multiple Sclerosis: A single tertiary centre experience. Sultan Qaboos University Medical Journal. 2025;25(1):225-232. doi:10.18295/2075-0528.2829
IEEE
G. K. H. Al-Hashmi, A. Al-Asmi, M. M. Islam, I. Al-Zakwani, M. Butt, A. Al Qassabi, H. Al-Abri, and A. R. Gujjar, "Effectiveness and Safety Profile of Fingolimod in Treating Omani Patients with Multiple Sclerosis: A single tertiary centre experience," Sultan Qaboos University Medical Journal, vol. 25, no. 1, pp. 225-232, 2025, doi: 10.18295/2075-0528.2829.