Abstract
This review investigated the effects of adjuvant vitamin D therapy on Total Nasal Symptoms Score (TNSS), IgE, and eosinophil counts in patients with allergic rhinitis (AR). The meta-analysis used databases, such as PubMed, Science Direct, Scopus, Web of Science, SAGE journals, and clinicaltrials.gov. Quality appraisal was performed using RoB 2 and NOS tools. The research was guided by the PRISMA 2020 chart and analyzed using RevMan 5.4. Sixteen articles, including 11 randomised controlled trials and five cohorts, met the inclusion criteria. Fourteen articles reported TNSS, while four reported IgE and eosinophil levels. Vitamin D significantly reduced TNSS (SMD -2.24; 95% confidence interval [CI]: -3.05, -1.43; P < 0.00001; I2 = 96%), IgE (SMD -1.45; 95% CI: -2.07 to -0.983; P < 0.00001; I2 = 79%), and eosinophil levels (SMD -2.20; 95% CI: -3.92 to -0.48; P = 0.01; I2 = 97%) in AR patients. Vitamin D adjuvant therapy significantly alleviated nasal symptoms and reduced IgE and eosinophil levels in patients with AR.
Publication details
- DOI
- 10.18295/2075-0528.2910
- Journal
- Sultan Qaboos University Medical Journal, 25(1), 867-875
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY-ND 4.0
Cite this article
APA 7
Surayya, R., Pawarti, D. R., Perdana, R. F., & Wungu, C. D. (2025). Effect of Adjuvant Vitamin D Therapy on Total Nasal Symptoms Score, IgE, and Eosinophil Levels in Allergic Rhinitis: A systematic review and meta-analysis. Sultan Qaboos University Medical Journal, 25(1), 867-875. https://doi.org/10.18295/2075-0528.2910
MLA 9
Surayya, Rahmi, et al. "Effect of Adjuvant Vitamin D Therapy on Total Nasal Symptoms Score, IgE, and Eosinophil Levels in Allergic Rhinitis: A systematic review and meta-analysis." Sultan Qaboos University Medical Journal, vol. 25, no. 1, 2025, pp. 867-875. https://doi.org/10.18295/2075-0528.2910.
Chicago (author–date)
Surayya, Rahmi, Dwi R. Pawarti, Rizka F. Perdana, and Citrawati D.K. Wungu. 2025. "Effect of Adjuvant Vitamin D Therapy on Total Nasal Symptoms Score, IgE, and Eosinophil Levels in Allergic Rhinitis: A systematic review and meta-analysis." Sultan Qaboos University Medical Journal 25 (1): 867-875. https://doi.org/10.18295/2075-0528.2910.
Harvard
Surayya, R., Pawarti, D. R., Perdana, R. F. and Wungu, C. D. (2025) 'Effect of Adjuvant Vitamin D Therapy on Total Nasal Symptoms Score, IgE, and Eosinophil Levels in Allergic Rhinitis: A systematic review and meta-analysis', Sultan Qaboos University Medical Journal, 25(1), pp. 867-875. doi:10.18295/2075-0528.2910.
Vancouver
Surayya R, Pawarti DR, Perdana RF, Wungu CD. Effect of Adjuvant Vitamin D Therapy on Total Nasal Symptoms Score, IgE, and Eosinophil Levels in Allergic Rhinitis: A systematic review and meta-analysis. Sultan Qaboos University Medical Journal. 2025;25(1):867-875. doi:10.18295/2075-0528.2910
IEEE
R. Surayya, D. R. Pawarti, R. F. Perdana, and C. D. Wungu, "Effect of Adjuvant Vitamin D Therapy on Total Nasal Symptoms Score, IgE, and Eosinophil Levels in Allergic Rhinitis: A systematic review and meta-analysis," Sultan Qaboos University Medical Journal, vol. 25, no. 1, pp. 867-875, 2025, doi: 10.18295/2075-0528.2910.