Abstract
Objectives: We sought to determine the effects of the delayed start protocol with gonadotropin-releasing hormone (GnRH) antagonists in poor responders undergoing in vitro fertilization (IVF). Methods: This randomized clinical trial was conducted during a 15-month period from April 2014 to July 2015 in clinics in Shiraz, Iran. A total of 42 poor responders with primary infertility were randomly assigned to the controlled ovarian stimulation group utilizing the delayed start protocol (n = 21) or the traditional group (n = 21) using GnRH antagonist, Cetrotide. The primary endpoint was the number of patients undergoing oocyte pick-up, implantation, and the rate of pregnancy. Results: The baseline characteristics of the two study groups were comparable including age, infertility duration, and body mass index. The number of follicles measuring > 13 mm in diameter (p = 0.057), retrieved oocytes (p = 0.564), mature metaphase II oocytes (p = 0.366), embryos (p = 0.709), and transferred embryos (p = 0.060) were comparable between the two groups. The number of patients undergoing oocyte pick-up (p = 0.311), the rates of implantation (p = 0.407), and pregnancy (p = 0.596) were also comparable between the two groups. Conclusions: The delayed start protocol was not associated with better conception results or cycle outcomes in poor responders with primary infertility undergoing IVF cycles.
Keywords
Publication details
- DOI
- 10.5001/omj.2018.92
- Journal
- Oman Medical Journal
- Publisher
- Oman Medical Specialty Board
- Open access
- Gold open access
Cite this article
APA 7
Zarei, A., Parsanezhad, M. E., Kutenaei, M. A., Jahromi, B. N., Esfahani, P. S., & Bakhshaei, P. (2018). Delayed Start Protocol with Gonadotropin-releasing Hormone Antagonist in Poor Responders Undergoing In Vitro Fertilization: A Randomized, Double-blinded, Clinical Trial. Oman Medical Journal. https://doi.org/10.5001/omj.2018.92
MLA 9
Zarei, Afsoon, et al. "Delayed Start Protocol with Gonadotropin-releasing Hormone Antagonist in Poor Responders Undergoing In Vitro Fertilization: A Randomized, Double-blinded, Clinical Trial." Oman Medical Journal, 2018. https://doi.org/10.5001/omj.2018.92.
Chicago (author–date)
Zarei, Afsoon, Mohammad Ebrahim Parsanezhad, Maryam Azizi Kutenaei, Bahia Namavar Jahromi, Parastoo Soheil Esfahani, and Pardis Bakhshaei. 2018. "Delayed Start Protocol with Gonadotropin-releasing Hormone Antagonist in Poor Responders Undergoing In Vitro Fertilization: A Randomized, Double-blinded, Clinical Trial." Oman Medical Journal. https://doi.org/10.5001/omj.2018.92.
Harvard
Zarei, A., Parsanezhad, M. E., Kutenaei, M. A., Jahromi, B. N., Esfahani, P. S. and Bakhshaei, P. (2018) 'Delayed Start Protocol with Gonadotropin-releasing Hormone Antagonist in Poor Responders Undergoing In Vitro Fertilization: A Randomized, Double-blinded, Clinical Trial', Oman Medical Journal. doi:10.5001/omj.2018.92.
Vancouver
Zarei A, Parsanezhad ME, Kutenaei MA, Jahromi BN, Esfahani PS, Bakhshaei P. Delayed Start Protocol with Gonadotropin-releasing Hormone Antagonist in Poor Responders Undergoing In Vitro Fertilization: A Randomized, Double-blinded, Clinical Trial. Oman Medical Journal. 2018. doi:10.5001/omj.2018.92
IEEE
A. Zarei, M. E. Parsanezhad, M. A. Kutenaei, B. N. Jahromi, P. S. Esfahani, and P. Bakhshaei, "Delayed Start Protocol with Gonadotropin-releasing Hormone Antagonist in Poor Responders Undergoing In Vitro Fertilization: A Randomized, Double-blinded, Clinical Trial," Oman Medical Journal, 2018, doi: 10.5001/omj.2018.92.