Abstract
An awake craniotomy is a continuously evolving technique used for the resection of brain tumours from the eloquent cortex. We report a 29-year-old male patient who presented to the Khoula Hospital, Muscat, Oman, in 2016 with a two month history of headaches and convulsions due to a space-occupying brain lesion in close proximity with the left motor cortex. An awake craniotomy was conducted using a scalp block, continuous dexmedetomidine infusion and a titrated ultra-low-dose of propofol-fentanyl. The patient remained comfortable throughout the procedure and the intraoperative neuropsychological tests, brain mapping and tumour resection were successful. This case report suggests that dexmedetomidine in combination with titrated ultra-low-dose propofolfentanyl are effective options during an awake craniotomy, ensuring optimum sedation, minimal disinhibition and a rapid recovery. To the best of the authors’ knowledge, this is the first awake craniotomy conducted successfully in Oman.
Publication details
- DOI
- 10.18295/squmj.2016.16.03.014
- Journal
- Sultan Qaboos University Medical Journal, 16(3), 347-351
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY-ND 4.0
Cite this article
APA 7
Das, S., Al-Mashani, A., Salhotra, N., Neeraj, & Chatterjee, N. (2025). Combination of Continuous Dexmedetomidine Infusion with Titrated Ultra-Low-Dose Propofol-Fentanyl for an Awake Craniotomy: Case report. Sultan Qaboos University Medical Journal, 16(3), 347-351. https://doi.org/10.18295/squmj.2016.16.03.014
MLA 9
Das, Samaresh, et al. "Combination of Continuous Dexmedetomidine Infusion with Titrated Ultra-Low-Dose Propofol-Fentanyl for an Awake Craniotomy: Case report." Sultan Qaboos University Medical Journal, vol. 16, no. 3, 2025, pp. 347-351. https://doi.org/10.18295/squmj.2016.16.03.014.
Chicago (author–date)
Das, Samaresh, Ali Al-Mashani, Neelam Salhotra, Neeraj, and Nilay Chatterjee. 2025. "Combination of Continuous Dexmedetomidine Infusion with Titrated Ultra-Low-Dose Propofol-Fentanyl for an Awake Craniotomy: Case report." Sultan Qaboos University Medical Journal 16 (3): 347-351. https://doi.org/10.18295/squmj.2016.16.03.014.
Harvard
Das, S., Al-Mashani, A., Salhotra, N., Neeraj and Chatterjee, N. (2025) 'Combination of Continuous Dexmedetomidine Infusion with Titrated Ultra-Low-Dose Propofol-Fentanyl for an Awake Craniotomy: Case report', Sultan Qaboos University Medical Journal, 16(3), pp. 347-351. doi:10.18295/squmj.2016.16.03.014.
Vancouver
Das S, Al-Mashani A, Salhotra N, Neeraj, Chatterjee N. Combination of Continuous Dexmedetomidine Infusion with Titrated Ultra-Low-Dose Propofol-Fentanyl for an Awake Craniotomy: Case report. Sultan Qaboos University Medical Journal. 2025;16(3):347-351. doi:10.18295/squmj.2016.16.03.014
IEEE
S. Das, A. Al-Mashani, N. Salhotra, Neeraj, and N. Chatterjee, "Combination of Continuous Dexmedetomidine Infusion with Titrated Ultra-Low-Dose Propofol-Fentanyl for an Awake Craniotomy: Case report," Sultan Qaboos University Medical Journal, vol. 16, no. 3, pp. 347-351, 2025, doi: 10.18295/squmj.2016.16.03.014.