Abstract
Chronic myeloid leukaemia (CML), previously a fatal illness, is now readily manageable with oral medication. First described in the 1840s, there was no widely accepted cure until the advent of allogeneic stem cell transplantation in the late 1970s. This treatment was of limited value because of donor availability and toxicity problems. Discovering the Philadelphia chromosome and demonstrating that the BCR-ABL chimaeric gene was responsible for the malignant phenotype opened new avenues. The development of tyrosine kinase inhibitors(TKIs) changed the lives of patients with CML. The treatment has been so successful that compliance is now a problem. Currently under discussion is the possible use of more expensive second generation TKIs for newly diagnosed patients. In spite of the success with TKIs, treatment of common cancers has not been so successful. Is CML therefore a paradigm for malignancy or just a strange disease?
Subject
Publication details
- DOI
- 10.18295/2075-0528.1401
- Journal
- Sultan Qaboos University Medical Journal, 12(4), 422-428
- Publisher
- Sultan Qaboos University
- Open access
- Gold open access
- License
- CC BY-ND 4.0
Cite this article
APA 7
McCann, S. R. (2025). Chronic Myeloid Leukaemia: A paradigm for malignancy or just a strange disease? Sultan Qaboos University Medical Journal, 12(4), 422-428. https://doi.org/10.18295/2075-0528.1401
MLA 9
McCann, Shaun R. "Chronic Myeloid Leukaemia: A paradigm for malignancy or just a strange disease?" Sultan Qaboos University Medical Journal, vol. 12, no. 4, 2025, pp. 422-428. https://doi.org/10.18295/2075-0528.1401.
Chicago (author–date)
McCann, Shaun R. 2025. "Chronic Myeloid Leukaemia: A paradigm for malignancy or just a strange disease?" Sultan Qaboos University Medical Journal 12 (4): 422-428. https://doi.org/10.18295/2075-0528.1401.
Harvard
McCann, S. R. (2025) 'Chronic Myeloid Leukaemia: A paradigm for malignancy or just a strange disease?', Sultan Qaboos University Medical Journal, 12(4), pp. 422-428. doi:10.18295/2075-0528.1401.
Vancouver
McCann SR. Chronic Myeloid Leukaemia: A paradigm for malignancy or just a strange disease? Sultan Qaboos University Medical Journal. 2025;12(4):422-428. doi:10.18295/2075-0528.1401
IEEE
S. R. McCann, "Chronic Myeloid Leukaemia: A paradigm for malignancy or just a strange disease?," Sultan Qaboos University Medical Journal, vol. 12, no. 4, pp. 422-428, 2025, doi: 10.18295/2075-0528.1401.