Abstract
[68Ga] DOTATATE as a radiolabeled tracer is used for in vivo detection of neuroendocrine tumors in the PET/CT examinations. This study aims to calculate S-values in various organs in a voxelized-based Monte Carlo simulation approach for each patient individually. PET/CT images of 9 patients suspected of neuroendocrine cancer were acquired 60 minutes after injection of [68Ga] DOTATATE. After reshaping and registering CT images to the size of PET images, GATE/GEANT4 Monte Carlo (MC) toolkit was used with two inputs of CT images as voxelized attenuation map and PET images as a voxelized activity map for the calculation of the different organs dose. Voxelized dose maps were extracted in the target organs for different source organs. S-value volume histogram and absolute S-values based on the MIRD formalism were calculated. The highest S-values were observed for spleen, bladder, kidneys, liver, pituitary, and the lung with 6.26E-05 ± 1.47E-05, 5.17E-05 ± 3.08E-05, 3.41E-05 ± 7.68E-06, 2.08E-05 ± 4.12E-06, 1.62E-05 ± 5.74E-06 and 8.47E-06 ± 2.47E-06 mGy/MBq.S, respectively. The difference between the amounts of the calculated S-values and those presented in OLINDA software is mainly related to the anatomical difference of the patients with the standard phantom in OLINEDA software. This study showed that patient-specific dosimetry is necessary to calculate S-values.
Keywords
Subject
Publication details
- DOI
- 10.24200/jon.2022.1018
- Journal
- Journal of Nuclear Research and Applications, 2(2), 30-40
- Publisher
- Nuclear Science and Technology Research Institute (NSTRI)
- Open access
- Gold open access
- License
- CC BY 4.0
Cite this article
APA 7
Karimkhani, S., Yousefnia, H., Faghihi, R., Gramifar, P., & Parishan, M. (2022). Calculation of Gallium-68 Dose Factors for [68Ga] DOTATATE Injected Patients: A Comparison with OLINDA Database. Journal of Nuclear Research and Applications, 2(2), 30-40. https://doi.org/10.24200/jon.2022.1018
MLA 9
Karimkhani, Samira, et al. "Calculation of Gallium-68 Dose Factors for [68Ga] DOTATATE Injected Patients: A Comparison with OLINDA Database." Journal of Nuclear Research and Applications, vol. 2, no. 2, 2022, pp. 30-40. https://doi.org/10.24200/jon.2022.1018.
Chicago (author–date)
Karimkhani, Samira, Hassan Yousefnia, Reza Faghihi, P. Gramifar, and Mohammadreza Parishan. 2022. "Calculation of Gallium-68 Dose Factors for [68Ga] DOTATATE Injected Patients: A Comparison with OLINDA Database." Journal of Nuclear Research and Applications 2 (2): 30-40. https://doi.org/10.24200/jon.2022.1018.
Harvard
Karimkhani, S., Yousefnia, H., Faghihi, R., Gramifar, P. and Parishan, M. (2022) 'Calculation of Gallium-68 Dose Factors for [68Ga] DOTATATE Injected Patients: A Comparison with OLINDA Database', Journal of Nuclear Research and Applications, 2(2), pp. 30-40. doi:10.24200/jon.2022.1018.
Vancouver
Karimkhani S, Yousefnia H, Faghihi R, Gramifar P, Parishan M. Calculation of Gallium-68 Dose Factors for [68Ga] DOTATATE Injected Patients: A Comparison with OLINDA Database. Journal of Nuclear Research and Applications. 2022;2(2):30-40. doi:10.24200/jon.2022.1018
IEEE
S. Karimkhani, H. Yousefnia, R. Faghihi, P. Gramifar, and M. Parishan, "Calculation of Gallium-68 Dose Factors for [68Ga] DOTATATE Injected Patients: A Comparison with OLINDA Database," Journal of Nuclear Research and Applications, vol. 2, no. 2, pp. 30-40, 2022, doi: 10.24200/jon.2022.1018.