Abstract
Background: There is no proven effective treatment for vision loss in central retinal vein occlusion (CRVO). Bevacizumab has been reported in small series with limited follow-up, to have a positive effect in reducing cystoid macular edema (CME) and improving vision in CRVO. Purpose: To report long-term results with the use of bevacizumab in CRVO. Materials and methods: Prospective interventional case series included 15 patients, serially evaluated with best corrected visual acuity (BCVA), optical coherence tomography (OCT), fluorescein angiography, and tonometry. Results were statistically analyzed. Results: Mean follow-up was 12 +/- 3.6 months (range, 6-18 months); mean number of injections was 2.2 (range, 1-4) per patient. Statistically significant reduction of macular thickness (P < 0.001) was seen at six weeks (mean, 346 mu); three months (mean, 353 mu); six months (mean, 348 mu); and final follow-up (mean, 342 mu). Significant BCVA improvement was seen at six weeks (mean, 0.27 logMAR), three months (mean, 0.3 logMAR), three months (0.15 logMAR), and final follow-up (mean, 0.21 logMAR) (P = 0.009). Also, 73.3% patients had BCVA improvement at the last follow-up. Conclusion: Intravitreal bevacizumab is an effective treatment option for CME in CRVO patients. Reinjections at appropriate timing, based on the OCT findings, are important for better visual outcome.
Keywords
Publication details
- DOI
- 10.4103/0974-620x.53036
- Journal
- Oman Journal of Ophthalmology, 2(2), 73-78
- Publisher
- Medknow Publications
- Open access
- Gold open access
Cite this article
APA 7
Manayath, G. J., Narendran, V., Al-Kharousi, N., & Wali, U. K. (2009). Bevacizumab therapy for macular edema in central retinal vein occlusion: Long-term results. Oman Journal of Ophthalmology, 2(2), 73-78. https://doi.org/10.4103/0974-620x.53036
MLA 9
Manayath, George J, et al. "Bevacizumab therapy for macular edema in central retinal vein occlusion: Long-term results." Oman Journal of Ophthalmology, vol. 2, no. 2, 2009, pp. 73-78. https://doi.org/10.4103/0974-620x.53036.
Chicago (author–date)
Manayath, George J, V Narendran, Nadia Al-Kharousi, and Upender K. Wali. 2009. "Bevacizumab therapy for macular edema in central retinal vein occlusion: Long-term results." Oman Journal of Ophthalmology 2 (2): 73-78. https://doi.org/10.4103/0974-620x.53036.
Harvard
Manayath, G. J., Narendran, V., Al-Kharousi, N. and Wali, U. K. (2009) 'Bevacizumab therapy for macular edema in central retinal vein occlusion: Long-term results', Oman Journal of Ophthalmology, 2(2), pp. 73-78. doi:10.4103/0974-620x.53036.
Vancouver
Manayath GJ, Narendran V, Al-Kharousi N, Wali UK. Bevacizumab therapy for macular edema in central retinal vein occlusion: Long-term results. Oman Journal of Ophthalmology. 2009;2(2):73-78. doi:10.4103/0974-620x.53036
IEEE
G. J. Manayath, V. Narendran, N. Al-Kharousi, and U. K. Wali, "Bevacizumab therapy for macular edema in central retinal vein occlusion: Long-term results," Oman Journal of Ophthalmology, vol. 2, no. 2, pp. 73-78, 2009, doi: 10.4103/0974-620x.53036.