Abstract
Type B insulin resistance syndrome (TBIRS) has not been previously reported in Arab populations. We report a case of TBIRS in an Arab patient with mixed connective tissue disease (MCTD). Investigations revealed a clinical condition marked by positive anti-insulin receptor and ribonucleoprotein antibodies. The patient presented with severe hyperglycemia, weight loss, arthralgia, and acanthosis nigricans. He was managed successfully with an intensive pulsed combination regimen of cyclophosphamide and plasmapheresis augmented with high doses of prednisolone, which normalized his blood sugar levels without insulin therapy. MCTD was controlled by hydroxychloroquine. During the course of his treatment, the patient developed diabetic ketoacidosis secondary to the gluteal abscess, leukopenia, and recurrent hypoglycemia. Here, we showed that immunosuppressive agents and plasmapheresis can induce remission of TBIRS and can be used to normalize the blood sugar levels of Arab patients with this condition.
Keywords
Publication details
- DOI
- 10.5001/omj.2020.52
- Journal
- Oman Medical Journal
- Publisher
- Oman Medical Specialty Board
- Open access
- Gold open access
Cite this article
APA 7
Aburisheh, K., Al Farsi, Y., Moyeen, F., & Mehmood, F. (2020). Association Between Type B Insulin Resistance Syndrome and Mixed Connective Tissue Disease in an Arab African Man. Oman Medical Journal. https://doi.org/10.5001/omj.2020.52
MLA 9
Aburisheh, Khaled, et al. "Association Between Type B Insulin Resistance Syndrome and Mixed Connective Tissue Disease in an Arab African Man." Oman Medical Journal, 2020. https://doi.org/10.5001/omj.2020.52.
Chicago (author–date)
Aburisheh, Khaled, Yousuf Al Farsi, Fauzia Moyeen, and Faryal Mehmood. 2020. "Association Between Type B Insulin Resistance Syndrome and Mixed Connective Tissue Disease in an Arab African Man." Oman Medical Journal. https://doi.org/10.5001/omj.2020.52.
Harvard
Aburisheh, K., Al Farsi, Y., Moyeen, F. and Mehmood, F. (2020) 'Association Between Type B Insulin Resistance Syndrome and Mixed Connective Tissue Disease in an Arab African Man', Oman Medical Journal. doi:10.5001/omj.2020.52.
Vancouver
Aburisheh K, Al Farsi Y, Moyeen F, Mehmood F. Association Between Type B Insulin Resistance Syndrome and Mixed Connective Tissue Disease in an Arab African Man. Oman Medical Journal. 2020. doi:10.5001/omj.2020.52
IEEE
K. Aburisheh, Y. Al Farsi, F. Moyeen, and F. Mehmood, "Association Between Type B Insulin Resistance Syndrome and Mixed Connective Tissue Disease in an Arab African Man," Oman Medical Journal, 2020, doi: 10.5001/omj.2020.52.