الملخص
Background: To evaluate the role of interferon alpha 2b (IFNα2b) in the management of primary/recurrent cases of ocular surface squamous neoplasia (OSSN). Methodology: Medical records of 27 OSSN cases managed with IFNα2b (topical drops and/or perilesional injection) in 1 year were retrospectively reviewed. Results: The median age of presentation was 60 years with a male: female ratio of 3.5:1. American Joint Commission on Cancer tumor grading was T1 in 1 eye (3.7%) and T3 in 26 eyes (96.3%). Eighteen cases were treated with topical drops (1 million IU/ml), 4 cases with perilesional subconjunctival injection (3-6 million IU/ml), and 5 cases with combined therapy. Overall, treatment response was seen in 88% cases. Complete regression was achieved in 80% cases. Median time to complete regression of tumor was 3 months (range 1-11 months) in cases treated with topical interferon therapy and 2.5 months (range 0.7-3 months) in cases managed with injections or a combination of the two. The mean duration of follow-up was 24 months. All cases with partial/no response showed complete regression on subsequent management with topical mitomycin C. None of the patients required surgery. Acute ocular surface congestion was seen in two patients necessitating discontinuation of therapy. Conclusion: In view of excellent treatment outcome and few side-effects, interferons can be considered as a primary, safe, and cost-effective treatment option for OSSN not only in tertiary centers but also by peripheral ophthalmologists.
الكلمات المفتاحية
بيانات النشر
- المعرّف الرقمي
- 10.4103/ojo.ojo_201_2018
- المجلة
- المجلة العُمانية لطب العيون, 14(1), 27-32
- الناشر
- منشورات ميدنو
- وصول مفتوح
- وصول مفتوح ذهبي
اقتبس هذه المقالة
APA 7
Meel, R., Dhiman, R., Vanathi, M., Sen, S., Gupta, N., & Tandon, R. (2021). Treatment outcome with interferon alpha 2b in ocular surface squamous neoplasia: Recommendation as primary treatment by peripheral ophthalmologists. Oman Journal of Ophthalmology, 14(1), 27-32. https://doi.org/10.4103/ojo.ojo_201_2018
MLA 9
Meel, Rachna, et al. "Treatment outcome with interferon alpha 2b in ocular surface squamous neoplasia: Recommendation as primary treatment by peripheral ophthalmologists." Oman Journal of Ophthalmology, vol. 14, no. 1, 2021, pp. 27-32. https://doi.org/10.4103/ojo.ojo_201_2018.
شيكاغو (المؤلف–التاريخ)
Meel, Rachna, Rebika Dhiman, Murugesan Vanathi, Seema Sen, Noopur Gupta, and Radhika Tandon. 2021. "Treatment outcome with interferon alpha 2b in ocular surface squamous neoplasia: Recommendation as primary treatment by peripheral ophthalmologists." Oman Journal of Ophthalmology 14 (1): 27-32. https://doi.org/10.4103/ojo.ojo_201_2018.
هارفارد
Meel, R., Dhiman, R., Vanathi, M., Sen, S., Gupta, N. and Tandon, R. (2021) 'Treatment outcome with interferon alpha 2b in ocular surface squamous neoplasia: Recommendation as primary treatment by peripheral ophthalmologists', Oman Journal of Ophthalmology, 14(1), pp. 27-32. doi:10.4103/ojo.ojo_201_2018.
فانكوفر
Meel R, Dhiman R, Vanathi M, Sen S, Gupta N, Tandon R. Treatment outcome with interferon alpha 2b in ocular surface squamous neoplasia: Recommendation as primary treatment by peripheral ophthalmologists. Oman Journal of Ophthalmology. 2021;14(1):27-32. doi:10.4103/ojo.ojo_201_2018
IEEE
R. Meel, R. Dhiman, M. Vanathi, S. Sen, N. Gupta, and R. Tandon, "Treatment outcome with interferon alpha 2b in ocular surface squamous neoplasia: Recommendation as primary treatment by peripheral ophthalmologists," Oman Journal of Ophthalmology, vol. 14, no. 1, pp. 27-32, 2021, doi: 10.4103/ojo.ojo_201_2018.