الملخص
Background: The high socioeconomic impact of osteoporosis and osteoporotic fracture is due to their high mortality, morbidity, and disease-related costs. Nowadays, bone mineral density (BMD) is a comparatively expensive way to diagnose and follow up patients with osteoporosis. Transforming growth factor-β3 (TGF-β3) is a protein categorized into cytokines. Some previous in vitro studies showed TGF-β3 effects on osteocytes and bone formation. Therefore, we conducted this study to find if there is any significant relationship between TGF-β3 and BMD results. Materials and Methods: This was an analytical cross-sectional study conducted in 2017. We included individuals who had been referred from their physicians to undergo BMD dual-energy X-ray absorptiometry. Blood samples were taken from 150 participants for measuring TGF-β3 with ELISA method. Results: The mean ± standard deviation of TGF-β3 serum level was 79 ± 30.8 pg/ml (minimum 41 pg/ml and maximum 210 pg/ml). There was a statistically significant and direct proportional relationship between TGF-β3 and T-score as a marker for the diagnosis and follow-up of osteoporosis and osteoporotic fracture ( P = 0.001) (Pearson's correlation = +0.95). Conclusion: There was a significant relationship between TGF-β3 serum level and BMD. TGF-β3 serum level may be used as a marker for the diagnosis and follow-up of osteoporosis and osteoporotic fracture.
الكلمات المفتاحية
الموضوع
بيانات النشر
- المعرّف الرقمي
- 10.4103/jrms.jrms_1062_18
- المجلة
- Journal of Research in Medical Sciences, 24(1), 46
- الناشر
- Wolters Kluwer Medknow Publications
- وصول مفتوح
- وصول مفتوح ذهبي
- الترخيص
- CC BY-NC-SA 4.0
اقتبس هذه المقالة
APA 7
Haghighizadeh, E., Shahrezaee, M., Sharifzadeh, S. R., & Momeni, M. (2019). Transforming growth factor-β3 relation with osteoporosis and osteoporotic fractures. Journal of Research in Medical Sciences, 24(1), 46. https://doi.org/10.4103/jrms.jrms_1062_18
MLA 9
Haghighizadeh, Ebrahim, et al. "Transforming growth factor-β3 relation with osteoporosis and osteoporotic fractures." Journal of Research in Medical Sciences, vol. 24, no. 1, 2019, pp. 46. https://doi.org/10.4103/jrms.jrms_1062_18.
شيكاغو (المؤلف–التاريخ)
Haghighizadeh, Ebrahim, Mostafa Shahrezaee, Seyyed Reza Sharifzadeh, and Mitra Momeni. 2019. "Transforming growth factor-β3 relation with osteoporosis and osteoporotic fractures." Journal of Research in Medical Sciences 24 (1): 46. https://doi.org/10.4103/jrms.jrms_1062_18.
هارفارد
Haghighizadeh, E., Shahrezaee, M., Sharifzadeh, S. R. and Momeni, M. (2019) 'Transforming growth factor-β3 relation with osteoporosis and osteoporotic fractures', Journal of Research in Medical Sciences, 24(1), pp. 46. doi:10.4103/jrms.jrms_1062_18.
فانكوفر
Haghighizadeh E, Shahrezaee M, Sharifzadeh SR, Momeni M. Transforming growth factor-β3 relation with osteoporosis and osteoporotic fractures. Journal of Research in Medical Sciences. 2019;24(1):46. doi:10.4103/jrms.jrms_1062_18
IEEE
E. Haghighizadeh, M. Shahrezaee, S. R. Sharifzadeh, and M. Momeni, "Transforming growth factor-β3 relation with osteoporosis and osteoporotic fractures," Journal of Research in Medical Sciences, vol. 24, no. 1, pp. 46, 2019, doi: 10.4103/jrms.jrms_1062_18.