الملخص
Objectives: Identification of the high risk alleles, genotypes and haplotypes of the human leukocyte antigens (HLA) in different populations is beneficial for understanding their roles in type 1 diabetes (T1D) pathogenesis and intervention practices. This study aimed to identify T1D-associated HLA gene alleles in the Omani population. Methods: The present case-control study included 73 diabetic seropositive children (mean age 9.08 ± 3.27 years) attending the paediatric clinic at Sultan Qaboos University Hospital in Muscat, Oman, and 110 healthy controls. HLA–A, -B, -C, -DRB1 and -DQB1 genes were genotyped using a sequence-specific primer polymerase chain reaction (SSP-PCR). Results: Two HLA class I alleles (B*08, B*58) and three class II alleles (DQB1*02, DRB1*03 and DRB1*04) were associated with T1D susceptibility, while one class I (B*51) and three class II (DQB1*05, DQB1*06 and DRB1*16) alleles were associated with T1D protection. HLA-DRB1*03 and DQB1*02 alleles showed the strongest risk association among all alleles. Six DRB1 residues (E9, S11, S13, Y30, V70 and K71) were significantly associated with T1D susceptibility. Heterozygous genotypes, HLA-DRB1*03/*04 and DQB1*02/*03 were significantly associated with T1D susceptibility (P <0.0001, odds ratio [OR] = 63.21 and P = 0.02, OR = 3.63, respectively). Furthermore, a significant combined action of DRB1*03-DQB1*02 haplotype in T1D risk (P = 0.000176, OR = 15) and DRB1*16-DQB1*05 haplotype in protection (P = 0.0312, OR = 0.48) was detected. Conclusion: Known HLA class II gene alleles are associated with T1D in Omani children.
بيانات النشر
- المعرّف الرقمي
- 10.18295/squmj.2.2022.016
- المجلة
- مجلة جامعة السلطان قابوس الطبية, 23(1), 68-75
- الناشر
- جامعة السلطان قابوس
- وصول مفتوح
- وصول مفتوح ذهبي
- الترخيص
- CC BY-ND 4.0
اقتبس هذه المقالة
APA 7
Al-Balushi, M., Al-Badi, S., Al-Yaarubi, S., Al-Riyami, H., Al Shidhani, A., Al-Hinai, S., Al Shirawi, A., Hasson, S., Said, E., Al-Jabri, A., & Al Ansari, A. (2025). The Association of Human Leukocyte Antigens Complex with Type 1 Diabetes in the Omani Population. Sultan Qaboos University Medical Journal, 23(1), 68-75. https://doi.org/10.18295/squmj.2.2022.016
MLA 9
Al-Balushi, Mohammed, et al. "The Association of Human Leukocyte Antigens Complex with Type 1 Diabetes in the Omani Population." Sultan Qaboos University Medical Journal, vol. 23, no. 1, 2025, pp. 68-75. https://doi.org/10.18295/squmj.2.2022.016.
شيكاغو (المؤلف–التاريخ)
Al-Balushi, Mohammed, Samiya Al-Badi, Saif Al-Yaarubi, Hamad Al-Riyami, Azza Al Shidhani, Shaima Al-Hinai, Ali Al Shirawi, Sidgi Hasson, Elias Said, Ali Al-Jabri, and Aliya Al Ansari. 2025. "The Association of Human Leukocyte Antigens Complex with Type 1 Diabetes in the Omani Population." Sultan Qaboos University Medical Journal 23 (1): 68-75. https://doi.org/10.18295/squmj.2.2022.016.
هارفارد
Al-Balushi, M., Al-Badi, S., Al-Yaarubi, S., Al-Riyami, H., Al Shidhani, A., Al-Hinai, S., Al Shirawi, A., Hasson, S., Said, E., Al-Jabri, A. and Al Ansari, A. (2025) 'The Association of Human Leukocyte Antigens Complex with Type 1 Diabetes in the Omani Population', Sultan Qaboos University Medical Journal, 23(1), pp. 68-75. doi:10.18295/squmj.2.2022.016.
فانكوفر
Al-Balushi M, Al-Badi S, Al-Yaarubi S, Al-Riyami H, Al Shidhani A, Al-Hinai S, et al. The Association of Human Leukocyte Antigens Complex with Type 1 Diabetes in the Omani Population. Sultan Qaboos University Medical Journal. 2025;23(1):68-75. doi:10.18295/squmj.2.2022.016
IEEE
M. Al-Balushi, S. Al-Badi, S. Al-Yaarubi, H. Al-Riyami, A. Al Shidhani, S. Al-Hinai, A. Al Shirawi, S. Hasson, E. Said, A. Al-Jabri, and A. Al Ansari, "The Association of Human Leukocyte Antigens Complex with Type 1 Diabetes in the Omani Population," Sultan Qaboos University Medical Journal, vol. 23, no. 1, pp. 68-75, 2025, doi: 10.18295/squmj.2.2022.016.