الملخص
Applying large language models to Traditional Chinese Medicine (TCM) prescription generation reveals three clinically critical gaps: models produce end-to-end mappings without auditable reasoning following the li-fa-fang-yao paradigm (SR Gap), treat each encounter in isolation without follow-up adjustment via sui zheng jia jian (LA Gap), and fail to enforce absolute contraindication rules such as Shi Ba Fan (SC Gap). We propose a progressive four-stage framework (SFT $\to$ PG-CoT $\to$ Dynamic $\to$ K-RL) that addresses each gap: PG-CoT constrains CoT distillation under the li-fa-fang-yao paradigm to produce auditable diagnostic chains, Dynamic SFT models patient trajectories with explicit transition reasoning, and K-RL encodes deterministic pharmacological rules as rule-based DPO preference signals. Across 12 fine-tuned models and 6 zero-shot baselines, our framework substantially improves prescription quality over zero-shot baselines---with a 7B model (Mistral-7B) surpassing zero-shot GPT-5 on all three TCM evaluation metrics.
الكلمات المفتاحية
الموضوع
بيانات النشر
- المجلة
- غير متاح
- وصول مفتوح
- وصول مفتوح أخضر
اقتبس هذه المقالة
APA 7
Chen, Z., Du, Z., Li, H., & Qin, P. (2026). Syndrome, Synergy, and Safety: Structured Reasoning and Knowledge-Driven Alignment for TCM Prescription Generation. https://omanscience.com/ar/articles/syndrome-synergy-and-safety-structured-reasoning-and-knowledge-driven-alignment-for-tcm-prescription-generation
MLA 9
Chen, Zheng, et al. "Syndrome, Synergy, and Safety: Structured Reasoning and Knowledge-Driven Alignment for TCM Prescription Generation." https://omanscience.com/ar/articles/syndrome-synergy-and-safety-structured-reasoning-and-knowledge-driven-alignment-for-tcm-prescription-generation.
شيكاغو (المؤلف–التاريخ)
Chen, Zheng, ZhiCheng Du, Haoxuan Li, and Peiwu Qin. 2026. "Syndrome, Synergy, and Safety: Structured Reasoning and Knowledge-Driven Alignment for TCM Prescription Generation." https://omanscience.com/ar/articles/syndrome-synergy-and-safety-structured-reasoning-and-knowledge-driven-alignment-for-tcm-prescription-generation.
هارفارد
Chen, Z., Du, Z., Li, H. and Qin, P. (2026) 'Syndrome, Synergy, and Safety: Structured Reasoning and Knowledge-Driven Alignment for TCM Prescription Generation', Available at: https://omanscience.com/ar/articles/syndrome-synergy-and-safety-structured-reasoning-and-knowledge-driven-alignment-for-tcm-prescription-generation.
فانكوفر
Chen Z, Du Z, Li H, Qin P. Syndrome, Synergy, and Safety: Structured Reasoning and Knowledge-Driven Alignment for TCM Prescription Generation. https://omanscience.com/ar/articles/syndrome-synergy-and-safety-structured-reasoning-and-knowledge-driven-alignment-for-tcm-prescription-generation
IEEE
Z. Chen, Z. Du, H. Li, and P. Qin, "Syndrome, Synergy, and Safety: Structured Reasoning and Knowledge-Driven Alignment for TCM Prescription Generation," https://omanscience.com/ar/articles/syndrome-synergy-and-safety-structured-reasoning-and-knowledge-driven-alignment-for-tcm-prescription-generation.