الملخص
Holoprosencephaly (HPE) is a developmental defect of the embryonic forebrain and midface. It is due to the non-cleavage of the embryonic forebrain into two cerebral hemispheres and the incomplete development of the paramedian structures. The overall prevalence is 1.31 per 10,000 births. The aetiology could be genetic,environmental, or both. HPE is classified into alobar, semilobar, and lobar subtypes based on the degree of separation of the cerebral hemispheres. We report two new cases of semilobar HPE with neurogenic hypernatraemia. Lack of thirst and hypodypsia associated with chronic hypernatraemia in patients with HPE is highly suggestive of neurogenic hypernatraemia. Early identification of neurogenic hypernatraemia is important as it improves with forced fluid therapy and does not require any medication.
بيانات النشر
- المعرّف الرقمي
- 10.18295/2075-0528.1508
- المجلة
- مجلة جامعة السلطان قابوس الطبية, 13(3), 463-466
- الناشر
- جامعة السلطان قابوس
- وصول مفتوح
- وصول مفتوح ذهبي
- الترخيص
- CC BY-ND 4.0
اقتبس هذه المقالة
APA 7
Javad, H., Al-Yarubi, S., Sankhla, A. P., Dilip, Al-Futasi, A., Abdelmogheth, A. A., & El-Naggari, M. (2025). Semilobar Holoprosencephaly with Neurogenic Hypernatraemia: Two new cases. Sultan Qaboos University Medical Journal, 13(3), 463-466. https://doi.org/10.18295/2075-0528.1508
MLA 9
Javad, Hashim, et al. "Semilobar Holoprosencephaly with Neurogenic Hypernatraemia: Two new cases." Sultan Qaboos University Medical Journal, vol. 13, no. 3, 2025, pp. 463-466. https://doi.org/10.18295/2075-0528.1508.
شيكاغو (المؤلف–التاريخ)
Javad, Hashim, Saif Al-Yarubi, Alexander P. Sankhla, Dilip, Amna Al-Futasi, Anas A. Abdelmogheth, and Mohamed El-Naggari. 2025. "Semilobar Holoprosencephaly with Neurogenic Hypernatraemia: Two new cases." Sultan Qaboos University Medical Journal 13 (3): 463-466. https://doi.org/10.18295/2075-0528.1508.
هارفارد
Javad, H., Al-Yarubi, S., Sankhla, A. P., Dilip, Al-Futasi, A., Abdelmogheth, A. A. and El-Naggari, M. (2025) 'Semilobar Holoprosencephaly with Neurogenic Hypernatraemia: Two new cases', Sultan Qaboos University Medical Journal, 13(3), pp. 463-466. doi:10.18295/2075-0528.1508.
فانكوفر
Javad H, Al-Yarubi S, Sankhla AP, Dilip, Al-Futasi A, Abdelmogheth AA, et al. Semilobar Holoprosencephaly with Neurogenic Hypernatraemia: Two new cases. Sultan Qaboos University Medical Journal. 2025;13(3):463-466. doi:10.18295/2075-0528.1508
IEEE
H. Javad, S. Al-Yarubi, A. P. Sankhla, Dilip, A. Al-Futasi, A. A. Abdelmogheth, and M. El-Naggari, "Semilobar Holoprosencephaly with Neurogenic Hypernatraemia: Two new cases," Sultan Qaboos University Medical Journal, vol. 13, no. 3, pp. 463-466, 2025, doi: 10.18295/2075-0528.1508.