الملخص
Ritonavir is a powerful inhibitor of the cytochrome P450 3A4 (CYP3A4) isoenzyme. It is used as a pharmaceutical enhancer in the management of HIV-positive patients. However, when co-administered with other drugs that are metabolised via the CYP3A4 pathway, ritonavir can potentially cause serious drug-drug interactions. Inhaled fluticasone propionate, which is used to treat asthma and chronic obstructive airway disease, is particularly prone to such interactions due to its physiological attributes. We report a HIV-positive 48-year-old male patient who presented to Al Nahdha Hospital, Muscat, Oman, in 2012 with weight loss, generalised weakness and fatigue and diagnosed with secondary adrenal insufficiency as a result of concomitant ritonavir and inhaled fluticasone.
بيانات النشر
- المعرّف الرقمي
- 10.18295/squmj.2017.17.03.014
- المجلة
- مجلة جامعة السلطان قابوس الطبية, 17(3), 339-342
- الناشر
- جامعة السلطان قابوس
- وصول مفتوح
- وصول مفتوح ذهبي
- الترخيص
- CC BY-ND 4.0
اقتبس هذه المقالة
APA 7
Al-Maqbali, A., Kamble, B., Elgalib, S., & Ali (2025). Secondary Adrenal Insufficiency Due to the Co-Administration of Ritonavir and Inhaled Fluticasone Propionate: Case report. Sultan Qaboos University Medical Journal, 17(3), 339-342. https://doi.org/10.18295/squmj.2017.17.03.014
MLA 9
Al-Maqbali, Ali, et al. "Secondary Adrenal Insufficiency Due to the Co-Administration of Ritonavir and Inhaled Fluticasone Propionate: Case report." Sultan Qaboos University Medical Journal, vol. 17, no. 3, 2025, pp. 339-342. https://doi.org/10.18295/squmj.2017.17.03.014.
شيكاغو (المؤلف–التاريخ)
Al-Maqbali, Ali, Bina Kamble, Salim Elgalib, and Ali. 2025. "Secondary Adrenal Insufficiency Due to the Co-Administration of Ritonavir and Inhaled Fluticasone Propionate: Case report." Sultan Qaboos University Medical Journal 17 (3): 339-342. https://doi.org/10.18295/squmj.2017.17.03.014.
هارفارد
Al-Maqbali, A., Kamble, B., Elgalib, S. and Ali (2025) 'Secondary Adrenal Insufficiency Due to the Co-Administration of Ritonavir and Inhaled Fluticasone Propionate: Case report', Sultan Qaboos University Medical Journal, 17(3), pp. 339-342. doi:10.18295/squmj.2017.17.03.014.
فانكوفر
Al-Maqbali A, Kamble B, Elgalib S, Ali. Secondary Adrenal Insufficiency Due to the Co-Administration of Ritonavir and Inhaled Fluticasone Propionate: Case report. Sultan Qaboos University Medical Journal. 2025;17(3):339-342. doi:10.18295/squmj.2017.17.03.014
IEEE
A. Al-Maqbali, B. Kamble, S. Elgalib, and Ali, "Secondary Adrenal Insufficiency Due to the Co-Administration of Ritonavir and Inhaled Fluticasone Propionate: Case report," Sultan Qaboos University Medical Journal, vol. 17, no. 3, pp. 339-342, 2025, doi: 10.18295/squmj.2017.17.03.014.