الملخص
Objective: This study aimed at evaluating advanced parental age as a risk factor for Autism Spectrum Disorder (ASD) in an Omani cohort. Methods: Case-control study of 278 ASD cases compared with 722 sex-matched controls retrieved from the electronic records of the Developmental Paediatric Clinic, Sultan Qaboos University Hospital (SQUH) between January 2015 and June 2016. Results: ASD cases (76.6% male) were mostly diagnosed between 3-4 years of age, with more than 50% of them originating from Muscat and Batinah governorates. Compared to controls, mothers from the case group had significantly higher educational level (post-secondary education versus high school/no formal education (odds-ratio (OR)=1.62; 95% C.I. 1.20-2.19). In a multivariate logistic regression, the odds ratio of maternal age as a risk for ASD increased dramatically with advancing age category (using age<25 as a reference, OR was 3.39, 6.12, 7.86 and 13.13 for age categories 25-29, 30-34, 35-39, and ≥40 years, respectively). The ORs of advancing paternal age as a risk for ASD were also statistically significant (using age<30 as referent, OR was 2.20, 2.36, and 3.12 for age categories 30-34, 35-39 and 40-44 years); however, there was a drop in the effect with paternal age ≥ 45 years (OR=1.42; 95% C.I .64-3.15). Conclusion: Both maternal and paternal increased age were associated with a higher risk of ASD; however, the association was more pronounced and more consistent with advanced maternal age compared to paternal age.
بيانات النشر
- المعرّف الرقمي
- 10.18295/squmj.4.2021.024
- المجلة
- مجلة جامعة السلطان قابوس الطبية, 21(3), 465-471
- الناشر
- جامعة السلطان قابوس
- وصول مفتوح
- وصول مفتوح ذهبي
- الترخيص
- CC BY-ND 4.0
اقتبس هذه المقالة
APA 7
Al-Mamari, W., Idris, A. B., Al-Zadjali, A. A., Jalees, S., Murthi, S., Al-Jabri, M., Gabr, A., & Fombonne, E. (2025). Parental Age and the Risk of Autism Spectrum Disorder in Oman: A case-control study. Sultan Qaboos University Medical Journal, 21(3), 465-471. https://doi.org/10.18295/squmj.4.2021.024
MLA 9
Al-Mamari, Watfa, et al. "Parental Age and the Risk of Autism Spectrum Disorder in Oman: A case-control study." Sultan Qaboos University Medical Journal, vol. 21, no. 3, 2025, pp. 465-471. https://doi.org/10.18295/squmj.4.2021.024.
شيكاغو (المؤلف–التاريخ)
Al-Mamari, Watfa, Ahmed B. Idris, Aala' A. Al-Zadjali, Saquib Jalees, Sathiya Murthi, Muna Al-Jabri, Ahlam Gabr, and Eric Fombonne. 2025. "Parental Age and the Risk of Autism Spectrum Disorder in Oman: A case-control study." Sultan Qaboos University Medical Journal 21 (3): 465-471. https://doi.org/10.18295/squmj.4.2021.024.
هارفارد
Al-Mamari, W., Idris, A. B., Al-Zadjali, A. A., Jalees, S., Murthi, S., Al-Jabri, M., Gabr, A. and Fombonne, E. (2025) 'Parental Age and the Risk of Autism Spectrum Disorder in Oman: A case-control study', Sultan Qaboos University Medical Journal, 21(3), pp. 465-471. doi:10.18295/squmj.4.2021.024.
فانكوفر
Al-Mamari W, Idris AB, Al-Zadjali AA, Jalees S, Murthi S, Al-Jabri M, et al. Parental Age and the Risk of Autism Spectrum Disorder in Oman: A case-control study. Sultan Qaboos University Medical Journal. 2025;21(3):465-471. doi:10.18295/squmj.4.2021.024
IEEE
W. Al-Mamari, A. B. Idris, A. A. Al-Zadjali, S. Jalees, S. Murthi, M. Al-Jabri, A. Gabr, and E. Fombonne, "Parental Age and the Risk of Autism Spectrum Disorder in Oman: A case-control study," Sultan Qaboos University Medical Journal, vol. 21, no. 3, pp. 465-471, 2025, doi: 10.18295/squmj.4.2021.024.