الملخص
Objectives: This study aimed to investigate the presence of oxidative stress and inflammation in ischaemic stroke patients by measuring malondialdehyde (MDA), total antioxidant status (TAS), and highly-sensitivity C-reactive protein (hsCRP) in the early post-ischaemic period, and to determine the role of Ginkgo biloba therapy in correcting the markers of oxidative stress and inflammation. Methods: This study was conducted at Ibn Seena Hospital, Mosul City, Iraq and included 31 cerebrovascular accident (CVA) patients and 30 healthy controls. Ischaemic stroke patients were divided into two groups: group I (n = 15) received conventional therapy; group II (n = 16) received conventional therapy with G. biloba (1500 mg/day) for 30 days. Blood samples were obtained from patients and controls before treatment and assays done of serum levels of MDA, TAS, and hsCRP. For CVA patients, a post-treatment blood sample was taken and the same parameters reassessed. Results: Compared with the controls, patients’ serum levels of MDA, and hsCRP were significantly higher (P ≤0.001) and TAS significantly lower. Group I and II patients reported a significant reduction in serum levels of MDA and hsCRP and a significant increase in serum levels of TAS, in comparison with pre-treatment levels. There was no significant difference (P = 0.19) in serum MDA levels between groups I and II, whereas, serum TAS levels were significantly higher (P ≤0.01) and hsCRP significantly lower (P ≤0.01) in group II. Conclusion: Acute stroke is associated with oxidative stress and inflammatory response in the early period. G. biloba plays a potential role in reducing oxidative damage and inflammatory response.
بيانات النشر
- المعرّف الرقمي
- 10.18295/2075-0528.1364
- المجلة
- مجلة جامعة السلطان قابوس الطبية, 12(2), 197-205
- الناشر
- جامعة السلطان قابوس
- وصول مفتوح
- وصول مفتوح ذهبي
- الترخيص
- CC BY-ND 4.0
اقتبس هذه المقالة
APA 7
Thanoon, I. A. J., Abdul-Jabbar, H. A., & A., D. (2025). Oxidative Stress and C-Reactive Protein in Patients with Cerebrovascular Accident (Ischaemic Stroke): The role of Ginkgo biloba extract. Sultan Qaboos University Medical Journal, 12(2), 197-205. https://doi.org/10.18295/2075-0528.1364
MLA 9
Thanoon, Imad A-J, et al. "Oxidative Stress and C-Reactive Protein in Patients with Cerebrovascular Accident (Ischaemic Stroke): The role of Ginkgo biloba extract." Sultan Qaboos University Medical Journal, vol. 12, no. 2, 2025, pp. 197-205. https://doi.org/10.18295/2075-0528.1364.
شيكاغو (المؤلف–التاريخ)
Thanoon, Imad A-J, Hilmy AS Abdul-Jabbar, and Dhia A. 2025. "Oxidative Stress and C-Reactive Protein in Patients with Cerebrovascular Accident (Ischaemic Stroke): The role of Ginkgo biloba extract." Sultan Qaboos University Medical Journal 12 (2): 197-205. https://doi.org/10.18295/2075-0528.1364.
هارفارد
Thanoon, I. A. J., Abdul-Jabbar, H. A. and A., D. (2025) 'Oxidative Stress and C-Reactive Protein in Patients with Cerebrovascular Accident (Ischaemic Stroke): The role of Ginkgo biloba extract', Sultan Qaboos University Medical Journal, 12(2), pp. 197-205. doi:10.18295/2075-0528.1364.
فانكوفر
Thanoon IAJ, Abdul-Jabbar HA, A. D. Oxidative Stress and C-Reactive Protein in Patients with Cerebrovascular Accident (Ischaemic Stroke): The role of Ginkgo biloba extract. Sultan Qaboos University Medical Journal. 2025;12(2):197-205. doi:10.18295/2075-0528.1364
IEEE
I. A. J. Thanoon, H. A. Abdul-Jabbar, and D. A., "Oxidative Stress and C-Reactive Protein in Patients with Cerebrovascular Accident (Ischaemic Stroke): The role of Ginkgo biloba extract," Sultan Qaboos University Medical Journal, vol. 12, no. 2, pp. 197-205, 2025, doi: 10.18295/2075-0528.1364.