الملخص
Objectives: Atypical squamous cells of undetermined significance (ASC-US) represent a diagnostic challenge during cervical cytology. This study aimed to review and identify high-risk human papillomavirus (HR-HPV) genotypes among previously diagnosed ASC-US cases in Kuwait. Methods: This retrospective study analysed 180 cases diagnosed as ASC-US between June 2017 and May 2018 at the Mubarak Al-Kabeer Hospital, Kuwait. Cervical specimens were assayed to determine the presence of HR-HPV DNA; subsequently, positive cases underwent genotyping and were categorised into three groups (HPV 16, HPV 18/45 and other HR-HPV types). Results: In total, ASC-US was confirmed in only 105 cases (58.3%), with the remaining cases reclassified as negative for intraepithelial lesions or malignancy (NILM; 32.2%) and epithelial cell abnormalities (ECA; 9.4%). Of these, HRHPV DNA was present in 20 ASC-US (19%), one NILM (1.7%) and six ECA (35.3%) cases. There were 62 Kuwaiti and 43 non-Kuwaiti women with confirmed ASC-US; of these, three (4.8%), six (9.7%) and four (6.5%) Kuwaitis and one (2.3%), one (2.3%) and five (11.6%) non-Kuwaitis had HPV 16, both HPV 16 and 18/45 and other HRHPV genotypes, respectively. Of those with HR-HPV DNA, the NILM case had the HPV 18/45 genotype, while the six ECA cases had the HPV 16 (n = 1), both HPV 16 and 18/45 (n = 1) and other HR-HPV (n = 4) genotypes. Conclusion: Overall, HR-HPV DNA was present in 19% of ASC-US cases compared to 1.7% of NILM cases initially misdiagnosed as ASC-US. Re-review of cervical cytology diagnoses may reduce unnecessary costs associated with HR-HPV genotyping.
بيانات النشر
- المعرّف الرقمي
- 10.18295/squmj.2020.20.04.007
- المجلة
- مجلة جامعة السلطان قابوس الطبية, 20(4), e318-323
- الناشر
- جامعة السلطان قابوس
- وصول مفتوح
- وصول مفتوح ذهبي
- الترخيص
- CC BY-ND 4.0
اقتبس هذه المقالة
APA 7
Kapila, K., Balakrishnan, M., Ali, R. H., Al-Juwaiser, A., George, S. S., & Mallik, M. K. (2025). Interpreting a Diagnosis of Atypical Squamous Cells of Undetermined Significance in Cervical Cytology and its Association with Human Papillomavirus: A retrospective analysis of 180 cases in Kuwait. Sultan Qaboos University Medical Journal, 20(4), e318-323. https://doi.org/10.18295/squmj.2020.20.04.007
MLA 9
Kapila, Kusum, et al. "Interpreting a Diagnosis of Atypical Squamous Cells of Undetermined Significance in Cervical Cytology and its Association with Human Papillomavirus: A retrospective analysis of 180 cases in Kuwait." Sultan Qaboos University Medical Journal, vol. 20, no. 4, 2025, pp. e318-323. https://doi.org/10.18295/squmj.2020.20.04.007.
شيكاغو (المؤلف–التاريخ)
Kapila, Kusum, Meera Balakrishnan, Rola H. Ali, Ahlam Al-Juwaiser, Sara S. George, and Mrinmay K. Mallik. 2025. "Interpreting a Diagnosis of Atypical Squamous Cells of Undetermined Significance in Cervical Cytology and its Association with Human Papillomavirus: A retrospective analysis of 180 cases in Kuwait." Sultan Qaboos University Medical Journal 20 (4): e318-323. https://doi.org/10.18295/squmj.2020.20.04.007.
هارفارد
Kapila, K., Balakrishnan, M., Ali, R. H., Al-Juwaiser, A., George, S. S. and Mallik, M. K. (2025) 'Interpreting a Diagnosis of Atypical Squamous Cells of Undetermined Significance in Cervical Cytology and its Association with Human Papillomavirus: A retrospective analysis of 180 cases in Kuwait', Sultan Qaboos University Medical Journal, 20(4), pp. e318-323. doi:10.18295/squmj.2020.20.04.007.
فانكوفر
Kapila K, Balakrishnan M, Ali RH, Al-Juwaiser A, George SS, Mallik MK. Interpreting a Diagnosis of Atypical Squamous Cells of Undetermined Significance in Cervical Cytology and its Association with Human Papillomavirus: A retrospective analysis of 180 cases in Kuwait. Sultan Qaboos University Medical Journal. 2025;20(4):e318-323. doi:10.18295/squmj.2020.20.04.007
IEEE
K. Kapila, M. Balakrishnan, R. H. Ali, A. Al-Juwaiser, S. S. George, and M. K. Mallik, "Interpreting a Diagnosis of Atypical Squamous Cells of Undetermined Significance in Cervical Cytology and its Association with Human Papillomavirus: A retrospective analysis of 180 cases in Kuwait," Sultan Qaboos University Medical Journal, vol. 20, no. 4, pp. e318-323, 2025, doi: 10.18295/squmj.2020.20.04.007.