الملخص
Objectives: Genetic predisposition is one of the factors that contribute to the etiology of heart failure (HF). This study aimed to compare the prevalence of human leukocyte antigen (HLA)-DQ2 and HLA-DQ8 haplotypes in patients with HF with reduced ejection fraction (HFrEF) and healthy controls. Methods: This case control study was conducted in Western Türkiye, and included 100 participants: 50 patients diagnosed with HFrEF and 50 healthy matching controls. The frequency and distribution of HLA-DQ2 and HLA-DQ8 were compared between the groups. Results: No statistically significant differences in haplotype distribution were observed between patients and controls for any of the assessed parameters. HLA-DQ2 positivity was observed in 16.0% of the HFrEF group and 20.0% of controls, while HLA-DQ8 positivity was found in 24.0% and 26.0%, respectively. Subgroup analyses stratified by sex and HF etiology also did not reveal differences. Conclusions: The HLA-DQ2 and HLA-DQ8 haplotypes are not significantly associated with HFrEF in the population studied. Therefore, the utility of these haplotypes as standalone markers for early detection of HFrEF appears limited.
الكلمات المفتاحية
بيانات النشر
- المعرّف الرقمي
- 10.5001/omj.2025.98
- المجلة
- مجلة عُمان الطبية, 40(4)
- الناشر
- المجلس العُماني للاختصاصات الطبية
- وصول مفتوح
- وصول مفتوح ذهبي
- الترخيص
- CC BY-NC 4.0
اقتبس هذه المقالة
APA 7
Küçük, U., Sılan, F., Gazi, E., Özdemir, Ö., Arslan, K., Sönmez, V., & Akşit, E. (2025). HLA-DQ2 and HLA-DQ8 Haplotypes in Heart Failure Patients with Reduced Ejection Fraction. Oman Medical Journal, 40(4). https://doi.org/10.5001/omj.2025.98
MLA 9
Küçük, Uğur, et al. "HLA-DQ2 and HLA-DQ8 Haplotypes in Heart Failure Patients with Reduced Ejection Fraction." Oman Medical Journal, vol. 40, no. 4, 2025. https://doi.org/10.5001/omj.2025.98.
شيكاغو (المؤلف–التاريخ)
Küçük, Uğur, Fatma Sılan, Emine Gazi, Öztürk Özdemir, Kadir Arslan, Volkan Sönmez, and Ercan Akşit. 2025. "HLA-DQ2 and HLA-DQ8 Haplotypes in Heart Failure Patients with Reduced Ejection Fraction." Oman Medical Journal 40 (4). https://doi.org/10.5001/omj.2025.98.
هارفارد
Küçük, U., Sılan, F., Gazi, E., Özdemir, Ö., Arslan, K., Sönmez, V. and Akşit, E. (2025) 'HLA-DQ2 and HLA-DQ8 Haplotypes in Heart Failure Patients with Reduced Ejection Fraction', Oman Medical Journal, 40(4). doi:10.5001/omj.2025.98.
فانكوفر
Küçük U, Sılan F, Gazi E, Özdemir Ö, Arslan K, Sönmez V, et al. HLA-DQ2 and HLA-DQ8 Haplotypes in Heart Failure Patients with Reduced Ejection Fraction. Oman Medical Journal. 2025;40(4). doi:10.5001/omj.2025.98
IEEE
U. Küçük, F. Sılan, E. Gazi, Ö. Özdemir, K. Arslan, V. Sönmez, and E. Akşit, "HLA-DQ2 and HLA-DQ8 Haplotypes in Heart Failure Patients with Reduced Ejection Fraction," Oman Medical Journal, vol. 40, no. 4, 2025, doi: 10.5001/omj.2025.98.