الملخص
Protein optimization aims to discover high-fitness sequences under a limited experimental budget. Existing machine-learning methods use task-specific predictors, biological priors, or ranking-aware objectives to guide which variants are tested in the next experimental round. However, these methods cannot adapt to shifts in the reliability of predictive evidence as measurements accumulate and ensure the correct ranking of key high-fitness candidates. To address these challenges, we propose Batch-Aligned Tail Arbitration (BATA), which uses experimental feedback to adaptively combine prior-informed and task-specific rankings for next-batch selection, with calibration focused on the batch-aligned high-fitness region. Across measured GB1, PABP, and TrpB landscapes, BATA achieves the best mean task rank (1.67) in final best fitness after 480 measurements. Controlled comparisons further show task-dependent gains from high-fitness calibration and batch alignment. Our work introduces feedback-calibrated predictor arbitration, where experimental feedback dynamically determines how predictive evidence guides next-batch selection, opening a new direction for protein optimization.
الكلمات المفتاحية
الموضوع
بيانات النشر
- المجلة
- غير متاح
- وصول مفتوح
- وصول مفتوح أخضر
اقتبس هذه المقالة
APA 7
Lin, Z., Fang, X., Fu, T., & Xu, X. (2026). Feedback-Calibrated Protein Optimization with Batch-Aligned Tail Arbitration. https://omanscience.com/ar/articles/feedback-calibrated-protein-optimization-with-batch-aligned-tail-arbitration
MLA 9
Lin, Zefeng, et al. "Feedback-Calibrated Protein Optimization with Batch-Aligned Tail Arbitration." https://omanscience.com/ar/articles/feedback-calibrated-protein-optimization-with-batch-aligned-tail-arbitration.
شيكاغو (المؤلف–التاريخ)
Lin, Zefeng, Xianyong Fang, Tianfan Fu, and Xiaohua Xu. 2026. "Feedback-Calibrated Protein Optimization with Batch-Aligned Tail Arbitration." https://omanscience.com/ar/articles/feedback-calibrated-protein-optimization-with-batch-aligned-tail-arbitration.
هارفارد
Lin, Z., Fang, X., Fu, T. and Xu, X. (2026) 'Feedback-Calibrated Protein Optimization with Batch-Aligned Tail Arbitration', Available at: https://omanscience.com/ar/articles/feedback-calibrated-protein-optimization-with-batch-aligned-tail-arbitration.
فانكوفر
Lin Z, Fang X, Fu T, Xu X. Feedback-Calibrated Protein Optimization with Batch-Aligned Tail Arbitration. https://omanscience.com/ar/articles/feedback-calibrated-protein-optimization-with-batch-aligned-tail-arbitration
IEEE
Z. Lin, X. Fang, T. Fu, and X. Xu, "Feedback-Calibrated Protein Optimization with Batch-Aligned Tail Arbitration," https://omanscience.com/ar/articles/feedback-calibrated-protein-optimization-with-batch-aligned-tail-arbitration.