الملخص
Background and objective: The objective of the study was to compare the efficacy of intravitreal bevacizumab (IVB) as monotherapy versus combination with modified macular grid (MMG) laser photocoagulation in the primary treatment of diffuse diabetic macular edema (DDME). Materials and methods: A prospective randomized trial was carried out in sixty eyes with DDME after Institutional Ethical clearance. Group A received three doses of IVB at a 1-month interval. Group B received MMG in addition to IVB. Complete examination including best-corrected visual acuity (BCVA) (Snellen's), central macular thickness (CMT) using spectral domain-optical coherence tomography was carried out at 0, 1, 4, 8, 12, and 24 weeks. Results: mean CMT at baseline, 12 and 24 weeks in Group A was 401 (±76), 280 (±49), and 307 (±46) and in Group B, 405 (±73), 237 (±33), and 242 (±45), respectively. Group B had significantly greater reductions (P < 0.001) from 12 weeks onward. BCVA and contrast sensitivity showed improvements with no significant difference. Conclusion: Combined therapy has more advantage in primary DDME by reducing CMT on longer follow-up.
الكلمات المفتاحية
بيانات النشر
- المعرّف الرقمي
- 10.4103/ojo.ojo_196_2016
- المجلة
- المجلة العُمانية لطب العيون, 11(3), 248-253
- الناشر
- منشورات ميدنو
- وصول مفتوح
- وصول مفتوح ذهبي
اقتبس هذه المقالة
APA 7
Das, G. K., Sahu, P. K., Biakthangi, L. V. L., & Jain, D. (2018). Evaluation of intravitreal bevacizumab as monotherapy and in combination with macular grid laser photocoagulation in diffuse diabetic macular edema. Oman Journal of Ophthalmology, 11(3), 248-253. https://doi.org/10.4103/ojo.ojo_196_2016
MLA 9
Das, Gopal K, et al. "Evaluation of intravitreal bevacizumab as monotherapy and in combination with macular grid laser photocoagulation in diffuse diabetic macular edema." Oman Journal of Ophthalmology, vol. 11, no. 3, 2018, pp. 248-253. https://doi.org/10.4103/ojo.ojo_196_2016.
شيكاغو (المؤلف–التاريخ)
Das, Gopal K, Pramod K Sahu, Laura V L Biakthangi, and Divya Jain. 2018. "Evaluation of intravitreal bevacizumab as monotherapy and in combination with macular grid laser photocoagulation in diffuse diabetic macular edema." Oman Journal of Ophthalmology 11 (3): 248-253. https://doi.org/10.4103/ojo.ojo_196_2016.
هارفارد
Das, G. K., Sahu, P. K., Biakthangi, L. V. L. and Jain, D. (2018) 'Evaluation of intravitreal bevacizumab as monotherapy and in combination with macular grid laser photocoagulation in diffuse diabetic macular edema', Oman Journal of Ophthalmology, 11(3), pp. 248-253. doi:10.4103/ojo.ojo_196_2016.
فانكوفر
Das GK, Sahu PK, Biakthangi LVL, Jain D. Evaluation of intravitreal bevacizumab as monotherapy and in combination with macular grid laser photocoagulation in diffuse diabetic macular edema. Oman Journal of Ophthalmology. 2018;11(3):248-253. doi:10.4103/ojo.ojo_196_2016
IEEE
G. K. Das, P. K. Sahu, L. V. L. Biakthangi, and D. Jain, "Evaluation of intravitreal bevacizumab as monotherapy and in combination with macular grid laser photocoagulation in diffuse diabetic macular edema," Oman Journal of Ophthalmology, vol. 11, no. 3, pp. 248-253, 2018, doi: 10.4103/ojo.ojo_196_2016.