الملخص
BACKGROUND: A retrospective study has shown lesser days of hospital stay in patients with increased levels of intra-operative end-tidal carbon dioxide (ETCO2). It is probable that hypercapnia may exert its beneficial effects on patients' outcome through optimization of global hemodynamic and tissue oxygenation, leading to a lower rate of post-operative complications. This study was designed to test the hypothesis that higher values of intra-operative ETCO2 decrease the rate of post-operative complications. MATERIALS AND METHODS: In this randomized, double-blind clinical trial, 78 adult patients scheduled for percutaneous nephrolithotomy (PCNL) were prospectively enrolled and randomly divided into three groups. ETCO2 was set and maintained throughout the procedure at 31-33, 37-39 and 43-45 mmHg in the hypocapnia, normocapnia and hypercapnia groups, respectively. The rates of post-operative complications were compared among the three groups. RESULTS: Seventy-five patients completed the study (52 male and 23 female). Ten (38.5%), four (16%) and two (8.3%) patients developed post-operative vomiting in the hypocapnia, normocapnia and hypercapnia groups, respectively (P = 0.025). The nausea score was significantly lower in the hypercapnic group compared with the other groups (3.9 ± 1.8, 3.2 ± 2.1 and 1.3 ± 1.8 in the hypocapnia, normocapnia and hypercapnia groups, respectively; P = 0.000). Time to return of spontaneous respiration and awakening were significantly decreased in the hypercapnia group compared with the other groups (P < 0.01). CONCLUSION: Mild intra-operative hypercapnia has a protecting effect against the development of post-operative nausea and vomiting and decreases the duration of emergence and recovery from general anesthesia.
الكلمات المفتاحية
الموضوع
بيانات النشر
- المعرّف الرقمي
- 10.4103/2277-9175.127997
- المجلة
- Advanced Biomedical Research, 3(1), 84
- الناشر
- Wolters Kluwer Medknow Publications
- وصول مفتوح
- وصول مفتوح ذهبي
- الترخيص
- CC BY-NC-SA 4.0
اقتبس هذه المقالة
APA 7
Golparvar, M., Saghaei, M., & Matin, G. (2014). Effects of intra-operative end-tidal carbon dioxide levels on the rates of post-operative complications in adults undergoing general anesthesia for percutaneous nephrolithotomy: A clinical trial. Advanced Biomedical Research, 3(1), 84. https://doi.org/10.4103/2277-9175.127997
MLA 9
Golparvar, Mohammad, et al. "Effects of intra-operative end-tidal carbon dioxide levels on the rates of post-operative complications in adults undergoing general anesthesia for percutaneous nephrolithotomy: A clinical trial." Advanced Biomedical Research, vol. 3, no. 1, 2014, pp. 84. https://doi.org/10.4103/2277-9175.127997.
شيكاغو (المؤلف–التاريخ)
Golparvar, Mohammad, Mahmoud Saghaei, and Gholamreza Matin. 2014. "Effects of intra-operative end-tidal carbon dioxide levels on the rates of post-operative complications in adults undergoing general anesthesia for percutaneous nephrolithotomy: A clinical trial." Advanced Biomedical Research 3 (1): 84. https://doi.org/10.4103/2277-9175.127997.
هارفارد
Golparvar, M., Saghaei, M. and Matin, G. (2014) 'Effects of intra-operative end-tidal carbon dioxide levels on the rates of post-operative complications in adults undergoing general anesthesia for percutaneous nephrolithotomy: A clinical trial', Advanced Biomedical Research, 3(1), pp. 84. doi:10.4103/2277-9175.127997.
فانكوفر
Golparvar M, Saghaei M, Matin G. Effects of intra-operative end-tidal carbon dioxide levels on the rates of post-operative complications in adults undergoing general anesthesia for percutaneous nephrolithotomy: A clinical trial. Advanced Biomedical Research. 2014;3(1):84. doi:10.4103/2277-9175.127997
IEEE
M. Golparvar, M. Saghaei, and G. Matin, "Effects of intra-operative end-tidal carbon dioxide levels on the rates of post-operative complications in adults undergoing general anesthesia for percutaneous nephrolithotomy: A clinical trial," Advanced Biomedical Research, vol. 3, no. 1, pp. 84, 2014, doi: 10.4103/2277-9175.127997.