الملخص
We report five cases of Cushing’s disease where the patients were given a therapeutic trial of cabergoline. Morning serum cortisol, adrenocorticotrophic hormone (ACTH), and sleeping cortisol concentrations were significantly raised. Magnetic resonance imaging (MRI) scans revealed pituitary microadenomas in 3 patients but were normal in the others. Ectopic ACTH production was excluded in the 2 patients with normal MRI scans. All were given a therapeutic trial of cabergoline (1 mg daily). Four patients responded with a prompt fall in serum cortisol levels and had a sustained clinical and biochemical remission for 378, 44, 28 and 14 days, respectively. One patient failed to respond. In conclusion, we suggest that all patients with Cushing’s disease should undergo a therapeutic trial of cabergoline. Responders can then be prepared for surgery or, if needed, treated medically in the long term.
بيانات النشر
- المعرّف الرقمي
- 10.18295/2075-0528.1411
- المجلة
- مجلة جامعة السلطان قابوس الطبية, 12(4), 493-497
- الناشر
- جامعة السلطان قابوس
- وصول مفتوح
- وصول مفتوح ذهبي
- الترخيص
- CC BY-ND 4.0
اقتبس هذه المقالة
APA 7
Elshafie, O., Osman, A., Al-Mamari, F., Ali, & Woodhouse, N. (2025). Cushing’s Disease: Sustained remission in five cases induced by medical therapy with the dopamine agonist cabergoline. Sultan Qaboos University Medical Journal, 12(4), 493-497. https://doi.org/10.18295/2075-0528.1411
MLA 9
Elshafie, Omayma, et al. "Cushing’s Disease: Sustained remission in five cases induced by medical therapy with the dopamine agonist cabergoline." Sultan Qaboos University Medical Journal, vol. 12, no. 4, 2025, pp. 493-497. https://doi.org/10.18295/2075-0528.1411.
شيكاغو (المؤلف–التاريخ)
Elshafie, Omayma, Anjum Osman, Fatima Al-Mamari, Ali, and NJY Woodhouse. 2025. "Cushing’s Disease: Sustained remission in five cases induced by medical therapy with the dopamine agonist cabergoline." Sultan Qaboos University Medical Journal 12 (4): 493-497. https://doi.org/10.18295/2075-0528.1411.
هارفارد
Elshafie, O., Osman, A., Al-Mamari, F., Ali and Woodhouse, N. (2025) 'Cushing’s Disease: Sustained remission in five cases induced by medical therapy with the dopamine agonist cabergoline', Sultan Qaboos University Medical Journal, 12(4), pp. 493-497. doi:10.18295/2075-0528.1411.
فانكوفر
Elshafie O, Osman A, Al-Mamari F, Ali, Woodhouse N. Cushing’s Disease: Sustained remission in five cases induced by medical therapy with the dopamine agonist cabergoline. Sultan Qaboos University Medical Journal. 2025;12(4):493-497. doi:10.18295/2075-0528.1411
IEEE
O. Elshafie, A. Osman, F. Al-Mamari, Ali, and N. Woodhouse, "Cushing’s Disease: Sustained remission in five cases induced by medical therapy with the dopamine agonist cabergoline," Sultan Qaboos University Medical Journal, vol. 12, no. 4, pp. 493-497, 2025, doi: 10.18295/2075-0528.1411.