الملخص
Objectives: This study aimed to describe correlations between glucose, insulin and adipokine levels and the homeostasis model assessment (HOMA) index with regards to the presence/absence of fat mass and obesity-associated (FTO) rs9939609 and peroxisome proliferator-activated receptor (PPAR)-y rs1801282 single nucleotide polymorphisms (SNPs) as indicators of body mass index in adolescents. Methods: This cross-sectional study was conducted between September and December 2016 in Toluca, Mexico. A total of 71 students between 14–18 years old were included. Various anthropometric and laboratory measurements were collected, including lipid profile, glucose, insulin and adipokine levels and HOMA index. The degree of association between variables was evaluated with regards to the presence/absence of the SNPs. Results: Leptin levels were significantly higher among female students (P = 0.001), although adiponectin levels did not differ significantly (P = 0.060). There were significant positive correlations between insulin levels and HOMA index with FTO (r = 0.391; P = 0.007 and r = 0.413; P = 0.005, respectively) and PPARγ (r = 0.529; P = 0.007 and r = 0.537; P = 0.007, respectively) SNPs. Leptin showed a significant positive correlation in the presence of PPARγ (r = 0.483; P = 0.007) or in the absence of both SNPs (r = 0.627; P = 0.039). However, adiponectin was significantly negatively correlated in the presence of FTO, either alone (r = −0.333; P = 0.024) or in combination with PPARγ (r = −0.616; P = 0.043). Conclusion: The presence of FTO and/or PPARγ SNPs might be related to a genetic predisposition to metabolic syndrome.
بيانات النشر
- المعرّف الرقمي
- 10.18295/squmj.2018.18.03.005
- المجلة
- مجلة جامعة السلطان قابوس الطبية, 18(3), e291-298
- الناشر
- جامعة السلطان قابوس
- وصول مفتوح
- وصول مفتوح ذهبي
- الترخيص
- CC BY-ND 4.0
اقتبس هذه المقالة
APA 7
Martínez-Martínez, M. D., Zerón, H. M., Layton-Tovar, L., F., C., Torres-García, R., Gutiérrez-Pliego, L. E., Camarillo-Romero, E., Garduño-García, J. D., & Camarillo-Romero, M. D. (2025). Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents. Sultan Qaboos University Medical Journal, 18(3), e291-298. https://doi.org/10.18295/squmj.2018.18.03.005
MLA 9
Martínez-Martínez, María D., et al. "Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents." Sultan Qaboos University Medical Journal, vol. 18, no. 3, 2025, pp. e291-298. https://doi.org/10.18295/squmj.2018.18.03.005.
شيكاغو (المؤلف–التاريخ)
Martínez-Martínez, María D., Hugo Mendieta Zerón, Luis Layton-Tovar, Cristian F., Rocío Torres-García, Laura E. Gutiérrez-Pliego, Eneida Camarillo-Romero, José D. Garduño-García, and María D. Camarillo-Romero. 2025. "Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents." Sultan Qaboos University Medical Journal 18 (3): e291-298. https://doi.org/10.18295/squmj.2018.18.03.005.
هارفارد
Martínez-Martínez, M. D., Zerón, H. M., Layton-Tovar, L., F., C., Torres-García, R., Gutiérrez-Pliego, L. E., Camarillo-Romero, E., Garduño-García, J. D. and Camarillo-Romero, M. D. (2025) 'Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents', Sultan Qaboos University Medical Journal, 18(3), pp. e291-298. doi:10.18295/squmj.2018.18.03.005.
فانكوفر
Martínez-Martínez MD, Zerón HM, Layton-Tovar L, F. C, Torres-García R, Gutiérrez-Pliego LE, et al. Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents. Sultan Qaboos University Medical Journal. 2025;18(3):e291-298. doi:10.18295/squmj.2018.18.03.005
IEEE
M. D. Martínez-Martínez, H. M. Zerón, L. Layton-Tovar, C. F., R. Torres-García, L. E. Gutiérrez-Pliego, E. Camarillo-Romero, J. D. Garduño-García, and M. D. Camarillo-Romero, "Correlation of the Homeostasis Model Assessment Index and Adiponectin, Leptin and Insulin Levels to Body Mass Index-Associated Gene Polymorphisms in Adolescents," Sultan Qaboos University Medical Journal, vol. 18, no. 3, pp. e291-298, 2025, doi: 10.18295/squmj.2018.18.03.005.