الملخص
Objectives: This study aimed to examine the association of angiotensin-converting enzyme (ACE) and glutathione S-transferase (GST) gene polymorphisms with body mass index (BMI) in hypertensive North Indians. Methods: This case-control study was carried out between May 2013 and November 2014 at the Era’s Lucknow Medical College & Hospital, Lucknow, India, and included 378 subjects divided into three groups. One group constituted 253 hypertensive individuals (sustained diastolic blood pressure of >90 mmHg and systolic blood pressure of >140 mmHg) who were subcategorised according to normal (<25 kg/m2) or high (≥25 kg/m2) BMI. The third group consisted of 125 age-, gender- and ethnically-matched normotensive controls with a normal BMI. Gene polymorphisms were evaluated by polymerase chain reaction. The genotypic and allelic frequency distribution among both groups were analysed. Results: A significant difference was found between GST theta 1-null and GST mu 1-positive genotype frequencies among the hypertensive overweight/obese individuals and controls (P = 0.014 and 0.033, respectively). However, no difference was observed in the frequency of ACE polymorphisms. ACE insertion/insertion genotype (P = 0.006), insertion and deletion alleles (P = 0.007 each) and GST theta 1-null and GST theta 1-positive genotypes (P = 0.006 each) were found to differ significantly between hypertensive cases and controls, regardless of BMI. Conclusion: ACE and GST gene polymorphisms were not associated with BMI but were significantly associated with hypertension among the studied group of North Indians.
بيانات النشر
- المعرّف الرقمي
- 10.18295/2075-0528.1731
- المجلة
- مجلة جامعة السلطان قابوس الطبية, 15(4), 477-485
- الناشر
- جامعة السلطان قابوس
- وصول مفتوح
- وصول مفتوح ذهبي
- الترخيص
- CC BY-ND 4.0
اقتبس هذه المقالة
APA 7
Rizvi, S., Raza, S. T., Abbas, Z., Shania, & Mahdi, F. (2025). Association of Angiotensin-Converting Enzyme and Glutathione S-Transferase Gene Polymorphisms with Body Mass Index among Hypertensive North Indians. Sultan Qaboos University Medical Journal, 15(4), 477-485. https://doi.org/10.18295/2075-0528.1731
MLA 9
Rizvi, Saliha, et al. "Association of Angiotensin-Converting Enzyme and Glutathione S-Transferase Gene Polymorphisms with Body Mass Index among Hypertensive North Indians." Sultan Qaboos University Medical Journal, vol. 15, no. 4, 2025, pp. 477-485. https://doi.org/10.18295/2075-0528.1731.
شيكاغو (المؤلف–التاريخ)
Rizvi, Saliha, Syed T. Raza, Zeba Abbas, Shania, and Farzana Mahdi. 2025. "Association of Angiotensin-Converting Enzyme and Glutathione S-Transferase Gene Polymorphisms with Body Mass Index among Hypertensive North Indians." Sultan Qaboos University Medical Journal 15 (4): 477-485. https://doi.org/10.18295/2075-0528.1731.
هارفارد
Rizvi, S., Raza, S. T., Abbas, Z., Shania and Mahdi, F. (2025) 'Association of Angiotensin-Converting Enzyme and Glutathione S-Transferase Gene Polymorphisms with Body Mass Index among Hypertensive North Indians', Sultan Qaboos University Medical Journal, 15(4), pp. 477-485. doi:10.18295/2075-0528.1731.
فانكوفر
Rizvi S, Raza ST, Abbas Z, Shania, Mahdi F. Association of Angiotensin-Converting Enzyme and Glutathione S-Transferase Gene Polymorphisms with Body Mass Index among Hypertensive North Indians. Sultan Qaboos University Medical Journal. 2025;15(4):477-485. doi:10.18295/2075-0528.1731
IEEE
S. Rizvi, S. T. Raza, Z. Abbas, Shania, and F. Mahdi, "Association of Angiotensin-Converting Enzyme and Glutathione S-Transferase Gene Polymorphisms with Body Mass Index among Hypertensive North Indians," Sultan Qaboos University Medical Journal, vol. 15, no. 4, pp. 477-485, 2025, doi: 10.18295/2075-0528.1731.