الملخص
Laboratories often face a new molecular assay with 16-64 labels and a bank of predictors whose training data and parameters are unavailable. The practical question is which frozen outputs to include in a small local model. AssayRouter treats completed assays as pseudo-targets and labels each candidate by its post-fit utility: the reduction in held-out discovery loss when the candidate is added to the local target predictor. A shared regressor learns to predict this utility from candidate behavior on the support set, without source identity; on a new assay, one frozen ranking selects four sources and separate labels fit a convex combiner. We train only on completed ChEMBL-MT assays and evaluate 24 external regression assays across six frozen interface families. AssayRouter-C lowers strict four-call negative log-likelihood (NLL) by 0.0409 relative to Support-CV@4. Frozen candidate-label permutations confirm that candidate-utility correspondence carries the transferred information, and leave-one-interface-out training shows that the mapping generalizes to unseen predictor families. Completed assays therefore provide transferable supervision for scarce-label routing through frozen prediction interfaces.
الكلمات المفتاحية
الموضوع
بيانات النشر
- المجلة
- غير متاح
- وصول مفتوح
- وصول مفتوح أخضر
اقتبس هذه المقالة
APA 7
Xu, D., Yang, Z., Wu, J., Zhang, S., Zhu, Z., Li, J., Zhang, J., & Ji, J. (2026). AssayRouter: Historical Utility Priors for Frozen Molecular Predictor Routing. https://omanscience.com/ar/articles/assayrouter-historical-utility-priors-for-frozen-molecular-predictor-routing
MLA 9
Xu, Dong, et al. "AssayRouter: Historical Utility Priors for Frozen Molecular Predictor Routing." https://omanscience.com/ar/articles/assayrouter-historical-utility-priors-for-frozen-molecular-predictor-routing.
شيكاغو (المؤلف–التاريخ)
Xu, Dong, Zhangfan Yang, Jiantao Wu, Shipeng Zhang, Zexuan Zhu, Jiangqiang Li, Jun Zhang, and Junkai Ji. 2026. "AssayRouter: Historical Utility Priors for Frozen Molecular Predictor Routing." https://omanscience.com/ar/articles/assayrouter-historical-utility-priors-for-frozen-molecular-predictor-routing.
هارفارد
Xu, D., Yang, Z., Wu, J., Zhang, S., Zhu, Z., Li, J., Zhang, J. and Ji, J. (2026) 'AssayRouter: Historical Utility Priors for Frozen Molecular Predictor Routing', Available at: https://omanscience.com/ar/articles/assayrouter-historical-utility-priors-for-frozen-molecular-predictor-routing.
فانكوفر
Xu D, Yang Z, Wu J, Zhang S, Zhu Z, Li J, et al. AssayRouter: Historical Utility Priors for Frozen Molecular Predictor Routing. https://omanscience.com/ar/articles/assayrouter-historical-utility-priors-for-frozen-molecular-predictor-routing
IEEE
D. Xu, Z. Yang, J. Wu, S. Zhang, Z. Zhu, J. Li, J. Zhang, and J. Ji, "AssayRouter: Historical Utility Priors for Frozen Molecular Predictor Routing," https://omanscience.com/ar/articles/assayrouter-historical-utility-priors-for-frozen-molecular-predictor-routing.