الملخص
BACKGROUND: Cardiac rehabilitation exerts anti-inflammatory effect on several cardiovascular diseases; however, these effects were not described for Chagas cardiomyopathy, which is associated with pro-inflammatory imbalance. MATERIALS AND METHODS: Ten patients with severe Chagas cardiomyopathy performed 8 months of exercise training in a cardiac rehabilitation program. Interleukin-1 beta (IL-1β), IL-8, IL-10, interferon gamma (IF-γ), tumor necrosis factor alpha (TNF-α), and monocyte chemoattractant protein-1 (MCP-1) serum levels were measured using enzyme-linked immunosorbent assay at baseline, 4, and 8 months. The influence of exercise on cytokine levels was evaluated using the one-way analysis of variance for repeated measurements, with Bonferroni posttest for multiple comparisons. RESULTS: Levels of pro-inflammatory (TNF-α, IL-1β, IL-8, IF-γ, and (MCP-1) and anti-inflammatory (IL-10) cytokines did not vary significantly during the observation period. CONCLUSION: Exercise may benefit patients with severe Chagas cardiomyopathy by curbing the production of pro-inflammatory cytokines in this disease characterized by a continuous state of inflammation.
الكلمات المفتاحية
الموضوع
بيانات النشر
- المعرّف الرقمي
- 10.4103/jrms.jrms_175_18
- المجلة
- Journal of Research in Medical Sciences, 25(1), 18
- الناشر
- Wolters Kluwer Medknow Publications
- وصول مفتوح
- وصول مفتوح ذهبي
- الترخيص
- CC BY 4.0
اقتبس هذه المقالة
APA 7
Mediano, M. F. F., Rodrigues, L. F., Mendes, F. D. S. N. S., Pinto, V. M., Silva, P. S. D., Silva, G. S. D., Pinheiro, R. O., & de Sousa, A. (2020). A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trial. Journal of Research in Medical Sciences, 25(1), 18. https://doi.org/10.4103/jrms.jrms_175_18
MLA 9
Mediano, Mauro Felippe Felix, et al. "A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trial." Journal of Research in Medical Sciences, vol. 25, no. 1, 2020, pp. 18. https://doi.org/10.4103/jrms.jrms_175_18.
شيكاغو (المؤلف–التاريخ)
Mediano, Mauro Felippe Felix, Luiz Fernando Rodrigues, Fernanda de Souza Nogueira Sardinha Mendes, VivianLiane Mattos Pinto, Paula Simplício da Silva, GilbertoMarcelo Sperandio da Silva, Roberta Olmo Pinheiro, and AndréaSilvestre de Sousa. 2020. "A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trial." Journal of Research in Medical Sciences 25 (1): 18. https://doi.org/10.4103/jrms.jrms_175_18.
هارفارد
Mediano, M. F. F., Rodrigues, L. F., Mendes, F. D. S. N. S., Pinto, V. M., Silva, P. S. D., Silva, G. S. D., Pinheiro, R. O. and de Sousa, A. (2020) 'A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trial', Journal of Research in Medical Sciences, 25(1), pp. 18. doi:10.4103/jrms.jrms_175_18.
فانكوفر
Mediano MFF, Rodrigues LF, Mendes FDSNS, Pinto VM, Silva PSD, Silva GSD, et al. A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trial. Journal of Research in Medical Sciences. 2020;25(1):18. doi:10.4103/jrms.jrms_175_18
IEEE
M. F. F. Mediano, L. F. Rodrigues, F. D. S. N. S. Mendes, V. M. Pinto, P. S. D. Silva, G. S. D. Silva, R. O. Pinheiro, and A. de Sousa, "A cardiac rehabilitation exercise program potentially inhibits progressive inflammation in patients with severe Chagas cardiomyopathy: A pilot single-arm clinical trial," Journal of Research in Medical Sciences, vol. 25, no. 1, pp. 18, 2020, doi: 10.4103/jrms.jrms_175_18.