[
    {
        "id": "osp-12764",
        "type": "article-journal",
        "title": "Trans-epithelial versus conventional corneal collagen crosslinking: A randomized trial in keratoconus",
        "author": [
            {
                "family": "Nawaz",
                "given": "Shah"
            },
            {
                "family": "Gupta",
                "given": "Shikha"
            },
            {
                "family": "Gogia",
                "given": "Varun"
            },
            {
                "family": "Sasikala",
                "given": "N K"
            },
            {
                "family": "Panda",
                "given": "Anita"
            }
        ],
        "URL": "https://omanscience.com/en/articles/trans-epithelial-versus-conventional-corneal-collagen-crosslinking-a-randomized-trial-in-keratoconus",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2015
                ]
            ]
        },
        "container-title": "Oman Journal of Ophthalmology",
        "volume": "8",
        "issue": "1",
        "page": "9-13",
        "DOI": "10.4103/0974-620x.149855",
        "publisher": "Medknow Publications",
        "ISSN": "0974-620X",
        "abstract": "Purpose: The purpose was to compare transepithelial versus epithelium off technique of corneal collagen crosslinking (CXL) in patients of keratoconus.\n\nMaterials and method: Totally, 40 eyes (40 patients) with progressive keratoconus were subjected to transepithelial CXL (20 eyes; Group I), and conventional CXL (20 eyes; Group II). Patients were evaluated for uncorrected distance visual acuity, best corrected visual acuity (BCVA), slit lamp-biomicroscopy, keratometry, 9-point pachymentry, orbscan II, and endothelial cell count at baseline and post CXL at 1, 3, and 6 months.\n\nResults: The two groups were similar with respect to the evaluated parameters both at baseline and at the end of 6 months. There was an improvement in mean BCVA from Log Mar 0.327 ± 0.1 (Group 1), 0.36 ± 0.08 (Group 2) to 0.23 ± 0.08 (Group 1; P < 0.001), 0.22 ± 0.06 (Group 2; P < 0.001), respectively, at 6 months. Mean Sim K astigmatism decreased from 6.6 ± 1.93 D (Group 1), 6.64 ± 1.93 D (Group 2) to 5.14 ± 1.86 D (Group 1; P = 0.001), and 4.77 ± 0.06 (Group 2; P = 0.001), respectively, at 6 months. The mean pachymetry increased from 432.05 ± 19.36 μm (Group 1), 429.91 ± 16.66 μm (Group 2) to 447.8 ± 16.09 μm (Group 1; P < 0.001), 440.25 ± 11.18 um (Group 2; P = 0.002), respectively, at 6 months. All cases showed stabilization of keratoconus two eyes in epithelium off group developed persistent stromal haze. Most of the patients in Group II experienced pain and photophobia during first 2 days, but not of Group I.\n\nConclusion: Trans-epithelial technique offers visual and topographic outcomes similar to the conventional method with superior patient comfort postintervention."
    }
]