[
    {
        "id": "osp-1301",
        "type": "article-journal",
        "title": "The Effect of Amantadine on Clomipramine Induced Sexual Dysfunction in Male Rats",
        "author": [
            {
                "family": "Devaangam",
                "given": "Sheshadri Shekar"
            },
            {
                "family": "S",
                "given": "Satyanarayana"
            },
            {
                "family": "K",
                "given": "Eswar Kumar"
            },
            {
                "family": "B",
                "given": "Vivek"
            },
            {
                "family": "C",
                "given": "Velmurugan"
            },
            {
                "family": "Kumar",
                "given": "Ashok"
            }
        ],
        "URL": "https://omanscience.com/en/articles/the-effect-of-amantadine-on-clomipramine-induced-sexual-dysfunction-in-male-rats",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2011
                ]
            ]
        },
        "container-title": "Oman Medical Journal",
        "DOI": "10.5001/omj.2011.104",
        "publisher": "Oman Medical Specialty Board",
        "ISSN": "1999-768X",
        "abstract": "Objective: Several studies have reported that Clomipramine has the ability to suppress male rat sexual behavior. Literature indicates that the activation of brain D2 receptors causes facilitation of penile erection, and a number of reports have indicated dopamine’s involvement in sexual function. Hence this study was undertaken to investigate the effect of Amantadine, a dopamine agonists on the Clomipramine induced sexual dysfunction. Methods: The study subjects involved a total of 48 males and 48 females, 4 months old Sprague-Dawley albino rats, all housed in a group of six males and females separately in plexi glass cages in an acclimatized colony room (25±0.5°C) maintained on a 12/12 hr light/dark cycle. The male rats were randomly divided into four groups of 12 male rats each. Group I served as controls. Group II, III, and IV were treated with Amantadine (9 mg/kg body weight, p.o) 30 min, prior to the treatment with 13.5 mg/kg, 27 mg/Kg and 54 mg/Kg bodyweight p.o of Clomipramine respectively for 60 days. The control group received vehicle 1 ml/kg p.o. The sexual behavior of the male rats was observed to determine the following parameters: mount latency, intromission latency, ejaculation latency, post ejaculatory pause, and intromission frequency. As well as the sexual behavior; serum testosterone and histopathology of the testes were also investigated in this study. Results: The results indicate that Amantadine in all aspects failed to antagonize Clomipramine induced sexual dysfunction in male rats. Even the sexual competence of male rats treated with 1/2 therapeutic dose (TD) of Clomipramine failed to regain their sexual competence in the presence of Amantadine. Testicular damage and decline in testosterone levels continued in the presence of Amantadine. Conclusion: Overall, the results suggest that Amantadine could not be a safe antidote to antagonize Clomipramine induced sexual dysfunction."
    }
]