[
    {
        "id": "osp-10157",
        "type": "article-journal",
        "title": "The Association of Human Leukocyte Antigens Complex with Type 1 Diabetes in the Omani Population",
        "author": [
            {
                "family": "Al-Balushi",
                "given": "Mohammed"
            },
            {
                "family": "Al-Badi",
                "given": "Samiya"
            },
            {
                "family": "Al-Yaarubi",
                "given": "Saif"
            },
            {
                "family": "Al-Riyami",
                "given": "Hamad"
            },
            {
                "family": "Al Shidhani",
                "given": "Azza"
            },
            {
                "family": "Al-Hinai",
                "given": "Shaima"
            },
            {
                "family": "Al Shirawi",
                "given": "Ali"
            },
            {
                "family": "Hasson",
                "given": "Sidgi"
            },
            {
                "family": "Said",
                "given": "Elias"
            },
            {
                "family": "Al-Jabri",
                "given": "Ali"
            },
            {
                "family": "Al Ansari",
                "given": "Aliya"
            }
        ],
        "URL": "https://omanscience.com/en/articles/the-association-of-human-leukocyte-antigens-complex-with-type-1-diabetes-in-the-omani-population",
        "language": "en",
        "issued": {
            "date-parts": [
                [
                    2025
                ]
            ]
        },
        "container-title": "Sultan Qaboos University Medical Journal",
        "volume": "23",
        "issue": "1",
        "page": "68-75",
        "DOI": "10.18295/squmj.2.2022.016",
        "publisher": "Sultan Qaboos University",
        "ISSN": "2075-051X",
        "abstract": "Objectives: Identification of the high risk alleles, genotypes and haplotypes of the human leukocyte antigens (HLA) in different populations is beneficial for understanding their roles in type 1 diabetes (T1D) pathogenesis and intervention practices. This study aimed to identify T1D-associated HLA gene alleles in the Omani population. Methods: The present case-control study included 73 diabetic seropositive children (mean age 9.08 ± 3.27 years) attending the paediatric clinic at Sultan Qaboos University Hospital in Muscat, Oman, and 110 healthy controls. HLA–A, -B, -C, -DRB1 and -DQB1 genes were genotyped using a sequence-specific primer polymerase chain reaction (SSP-PCR). Results: Two HLA class I alleles (B*08, B*58) and three class II alleles (DQB1*02, DRB1*03 and DRB1*04) were associated with T1D susceptibility, while one class I (B*51) and three class II (DQB1*05, DQB1*06 and DRB1*16) alleles were associated with T1D protection. HLA-DRB1*03 and DQB1*02 alleles showed the strongest risk association among all alleles. Six DRB1 residues (E9, S11, S13, Y30, V70 and K71) were significantly associated with T1D susceptibility. Heterozygous genotypes, HLA-DRB1*03/*04 and DQB1*02/*03 were significantly associated with T1D susceptibility (P"
    }
]